| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
The fundamental properties of circadian clocks, such like temperature compensation and nonlinearity, has not been understood. We focus on molecular properties of clock proteins in order to elucidate molecular mechanisms for these properties. The interaction between CKIε and PER-peptide is altered in accordance with phosphorylation states of PER-peptide. These results suggest that the interaction with PERIOD and the enzymatic activity of CKIε are the key processes defining the fundamental properties of the mammalian circadian clock.
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