Biochemical analysis of mammalian clock proteins
| Project/Area Number |
21770153
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional biochemistry
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
NAKAJIMA Masato The Institute of Physical and Chemical Research, システムバイオロジー研究プロジェクト, 研究員 (50432232)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 概日時計 / 温度補償性 / リン酸化反応 / 酵素基質相互作用 / CKIε/δ / タンパク質間相互作用 / タンパク質大量発現 / CKIε / δ |
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| Research Abstract |
The fundamental properties of circadian clocks, such like temperature compensation and nonlinearity, has not been understood. We focus on molecular properties of clock proteins in order to elucidate molecular mechanisms for these properties. The interaction between CKIε and PER-peptide is altered in accordance with phosphorylation states of PER-peptide. These results suggest that the interaction with PERIOD and the enzymatic activity of CKIε are the key processes defining the fundamental properties of the mammalian circadian clock.
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Report
(3 results)
Research Products
(8 results)
