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Biochemical analysis of mammalian clock proteins

Research Project

Project/Area Number 21770153
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Functional biochemistry
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

NAKAJIMA Masato  The Institute of Physical and Chemical Research, システムバイオロジー研究プロジェクト, 研究員 (50432232)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords概日時計 / 温度補償性 / リン酸化反応 / 酵素基質相互作用 / CKIε/δ / タンパク質間相互作用 / タンパク質大量発現 / CKIε / δ
Research Abstract

The fundamental properties of circadian clocks, such like temperature compensation and nonlinearity, has not been understood. We focus on molecular properties of clock proteins in order to elucidate molecular mechanisms for these properties. The interaction between CKIε and PER-peptide is altered in accordance with phosphorylation states of PER-peptide. These results suggest that the interaction with PERIOD and the enzymatic activity of CKIε are the key processes defining the fundamental properties of the mammalian circadian clock.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report

Research Products

(8 results)

All 2011 2010 2009

All Journal Article (3 results) Presentation (5 results)

  • [Journal Article] 概日時計システムの生化学および構成的アプローチ2011

    • Author(s)
      中嶋正人
    • Journal Title

      生化学

      Volume: 83 Pages: 41-45

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 概日時計研究における生化学および構成的アプローチ2010

    • Author(s)
      中嶋正人
    • Journal Title

      生化学 Vol.83(1)

      Pages: 41-45

    • Related Report
      2010 Final Research Report
  • [Journal Article] Temperature-insensitive reaction in the mammalian circadian clock.2009

    • Author(s)
      Nakajima M., Ukai H., Isojima Y., Hiroki R., Ueda,A
    • Journal Title

      Sleep and Biological Rhythms 7

      Pages: 243-251

    • Related Report
      2010 Final Research Report
  • [Presentation] 哺乳類概日時計における温度補償性の解析と制御2010

    • Author(s)
      中嶋正人、小山洋平、鵜飼英樹、上田泰己
    • Organizer
      第17回日本時間生物学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] 概日時計システムの蛋白質科学2010

    • Author(s)
      中嶋正人、小山洋平、上田泰己
    • Organizer
      第10回日本蛋白質科学会年会
    • Place of Presentation
      札幌
    • Related Report
      2010 Final Research Report
  • [Presentation] 概日時計システムの蛋白質科学2010

    • Author(s)
      中嶋正人, 他3名
    • Organizer
      第10回日本蛋白質科学会年会
    • Place of Presentation
      札幌コンベンションセンター、札幌
    • Related Report
      2010 Annual Research Report
  • [Presentation] 哺乳類概日時計における温度補償性の解析と制御2010

    • Author(s)
      中嶋正人、小山洋平、上田泰己
    • Organizer
      第17回日本時間生物学会学術大会
    • Place of Presentation
      早稲田大学国際会議場、東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 哺乳類概日時計における温度補償性の同定・解析・設計2009

    • Author(s)
      中嶋正人
    • Organizer
      「細胞を創る」研究会2.0
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report

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Published: 2009-03-31   Modified: 2016-04-21  

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