Cancer cell recognition by an activating-type Siglec

Research Project

Project/Area Number	21770155
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Functional biochemistry
Research Institution	The Institute of Physical and Chemical Research (2011) Osaka University (2009-2010)
Principal Investigator	ANGATA Takashi 独立行政法人理化学研究所, 糖鎖認識研究チーム, チームリーダー (40371017)
Project Period (FY)	2009 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	癌 / 免疫 / シアル酸 / シアリルTn / レクチン / シグレック / 上皮間葉転換 / TGF-β / シグナル伝達 / 糖鎖 / 免疫学
Research Abstract	Siglec-15 is one of the receptors that recognize glycans containing sialic acids, and is involved in the immune cell activation. In this study, we identified a soluble factor that induces expression of Siglec-15 on myeloid cells. We also found that the interaction between glycan ligand on tumor cells and Siglec-15 on myeloid cells induces enhanced myeloid expression of TGF-β, which is involved in epithelial-mesenchymal transition of cancer cells.

Report

(4 results)