Nano-scale analysis and computational fluid mechanics of the flow on the surface of tracheal lumen
| Project/Area Number |
21770158
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biophysics
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| Research Institution | Tohoku University |
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Principal Investigator |
UENO Hironori 東北大学, 国際高等研究教育機構, 助教 (70518240)
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| Research Collaborator |
ISHIKAWA Takuji 東北大学, 大学院・工学研究科 (20313728)
ISHIKAWA Takashi ポールシェラ研究所
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 繊毛・鞭毛 / 気管 / ダイニン / クライオ電子線トモグラフィー法 / 数値シミュレーション / 気管上皮細胞 |
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| Research Abstract |
Mucociliary clearance on the surface of the tracheal lumen is an important component of lung defense against viruses and bacteria. We analyzed the detail of ciliary movement with high spatial precision by labeling the ciliary tip using quantum dots, and axonemal structure by cryo-electron tomography. We revealed the overall directional flow from the lungs to the oropharynx on tracheal lumen by effective ciliary motion with the asymmetric axonemal structure. Moreover, we discovered that collective swimming of microorganisms is the most energy-efficient way of moving. And also, we developed new program code and GPGPU computational system to analyze the fluid flow mechanism on the surface of tracheal lumen.
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Report
(4 results)
Research Products
(38 results)
