| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
Mucociliary clearance on the surface of the tracheal lumen is an important component of lung defense against viruses and bacteria. We analyzed the detail of ciliary movement with high spatial precision by labeling the ciliary tip using quantum dots, and axonemal structure by cryo-electron tomography. We revealed the overall directional flow from the lungs to the oropharynx on tracheal lumen by effective ciliary motion with the asymmetric axonemal structure. Moreover, we discovered that collective swimming of microorganisms is the most energy-efficient way of moving. And also, we developed new program code and GPGPU computational system to analyze the fluid flow mechanism on the surface of tracheal lumen.
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