Neutron crystallographic analysis of human transthyretin
| Project/Area Number |
21770159
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biophysics
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| Research Institution | University of Toyama (2011)
Ibaraki University (2009-2010) |
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Principal Investigator |
YOKOYAMA Takeshi 富山大学, 大学院・医学薬学研究部(薬学), 助教 (50524162)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 中性子結晶構造解析 / 構造生物学 / アミロイドーシス |
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| Research Abstract |
Towards to the neutron crytallographic analysis, crystallization of large crytals and neutron diffraction data collection were carried out, and we succeeded to determine the neutron crystal structure of transthyretin. Neutron structure revealed the structural stability and molecular pH sensitivity, related to the amyloid fibril formation.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Hydrogen-bond network and pH sensitivity in transthyretin : Neutron crystal structure of human transthyretin2012
Author(s)
Yokoyama T., Mizuguchi M., Nabeshima Y., Kusaka K., Yamada T., Hosoya T., Ohhara T., Kurihara K., Tomoyori K., Tanaka I., Niimura N.
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Journal Title
J. Struct. Biol
Volume: 177-2
Pages: 283-290
Related Report
Peer Reviewed
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[Presentation] 変異体トランスサイレチンの中性子回折測定及びX線結晶構造解析2010
Author(s)
Yokoyama T., Nabeshima Y., Hosoya T., Ohhara T., Kurihara K., Kusaka K., Mizuguchi M., Tanaka I., Niimura N.
Organizer
第48回日本生物物理学会年会
Place of Presentation
仙台(ポスター発表)
Year and Date
2010-09-20
Related Report
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