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Computational analysis of electron/proton transfer in membrane protein complexes

Research Project

Project/Area Number 21770163
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biophysics
Research InstitutionKyoto University

Principal Investigator

ISHIKITA Hiroshi  Kyoto University, 生命科学系キャリアパス形成ユニット, 特定助教 (00508111)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords光生物 / 蛋白質 / 酵素反応 / 電子移動反応 / 生体生命情報学 / 生物物理
Research Abstract

Electron/proton transfer reactions in membrane-protein complexes or enzymes were analyzed using computational approaches and protein crystal structures. As a result, contributions of the protein environments to (i) protonation/deprotonation reactions in the proton binding sites or (ii) redox potentials of the redox active sites were revealed in the present study.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (36 results)

All 2011 2010 2009 Other

All Journal Article (10 results) (of which Peer Reviewed: 9 results) Presentation (23 results) Remarks (3 results)

  • [Journal Article] Proton-binding sites of acid-sensing ion channel 12011

    • Author(s)
      Hiroshi Ishikita
    • Journal Title

      PLoS One 6

    • NAID

      120005241354

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rubredoxin function : redox behavior from electrostatics2011

    • Author(s)
      Ana Patricia Gamiz-Hernandez, Gernot Kieseritzky, Hiroshi Ishikita Ernst-Walter Knapp
    • Journal Title

      J.Chem.Theory Comput. 7

      Pages: 742-752

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proton-binding sites of acid-sensing ion channel 12011

    • Author(s)
      Hiroshi Ishikita
    • Journal Title

      PLoS One

      Volume: 6

    • NAID

      120005241354

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rubredoxin function : redox behavior from electrostatics2011

    • Author(s)
      Ana Patricia Gamiz-Hernandez, Gernot Kieseritzky, Hiroshi Ishikita, Ernst-Walter Knapp
    • Journal Title

      J.Chem.Theory Comput.

      Volume: 7 Pages: 742-752

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Origin of the pKa shift of the catalytic lysine in acetoacetate decarboxylase2010

    • Author(s)
      Hiroshi Ishikita
    • Journal Title

      FEBS Lett 584

      Pages: 3464-3468

    • NAID

      120005241434

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 生物物理学会会誌総説「光合成蛋白質における酸化還元電位制御の理論解析2010

    • Author(s)
      石北央
    • Journal Title

      生物物理 209

    • Related Report
      2010 Final Research Report
  • [Journal Article] Origin of the pKa shift of the catalytic lysine in acetoacetate decarboxy lase2010

    • Author(s)
      Hiroshi Ishikita
    • Journal Title

      FEBS Lett.

      Volume: 584 Pages: 3464-3468

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 総説「光合成蛋白質における酸化還元電位制御の理論解析」2010

    • Author(s)
      Hiroshi Ishikita
    • Journal Title

      生物物理

      Volume: 50 Pages: 286-289

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxidation power of the chlorophyll pair P680 in Photosystem II2009

    • Author(s)
      Hiroshi Ishikita, E.-W.Knapp
    • Journal Title

      J.Biol.Inorg.Chem.(Supplement 1,173) 14

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] How does the Q_B site influence propagate to the Q_A site in Photosystem II?

    • Author(s)
      Hiroshi Ishikita, Koji Hasegawa, Takumi Noguchi
    • Journal Title

      Biochemistry (in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] さきがけ研究領域合同シンポジウム「人類の危機に挑む研究開発:光と太陽エネルギー」2011

    • Organizer
      JST
    • Place of Presentation
      神奈川大学、神奈川
    • Year and Date
      2011-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] 光合成反応中心蛋白質の電子移動2011

    • Author(s)
      石北央
    • Organizer
      日本科学会第91春季年会JSTさきがけ研究領域合同シンポジウム「人類の危機に挑む研究開発:光と太陽エネルギー」
    • Place of Presentation
      神奈川大学(横浜)
    • Year and Date
      2011-03-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] 光合成反応中心タンパク質における酸化還元電位の理論解析2011

    • Author(s)
      石北央
    • Organizer
      分子科学研究所オープンセミナー
    • Place of Presentation
      分子科学研究所、愛知
    • Year and Date
      2011-01-20
    • Related Report
      2010 Final Research Report
  • [Presentation] 光合成反応中心タンパク質における酸化還元電位の理論解析2011

    • Author(s)
      石北央
    • Organizer
      分子科学研究所オープンセミナー
    • Place of Presentation
      分子科学研究所(愛知)(招待講演)
    • Year and Date
      2011-01-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 水分子酸化を可能とする光合成系II内の電子移動2011

    • Author(s)
      石北央
    • Organizer
      日本物理学会第66回年次大会
    • Place of Presentation
      新潟大学、新潟
    • Related Report
      2010 Final Research Report
  • [Presentation] 水分子酸化を可能とする光合成反応中心蛋白質の電子移動2011

    • Author(s)
      石北央
    • Organizer
      大阪大学蛋白質研究所セミナー「分子科学と生理学が解き明かす植物の光エネルギー変換の新展開」
    • Place of Presentation
      大阪大学蛋白質研究所
    • Related Report
      2010 Final Research Report
  • [Presentation] Oxidation power of the chlorophyll pair P680 in Photosystem II2011

    • Author(s)
      Hiroshi Ishikita
    • Organizer
      日本-フィンランド2国間セミナー「Future prospects of photosynthetic organisms : from genomes to environment」
    • Place of Presentation
      岡山ロイヤルホテル、岡山
    • Related Report
      2010 Final Research Report
  • [Presentation] Oxidation power of the chlorophyll pair P680 in Photosystem II2011

    • Author(s)
      石北央
    • Organizer
      日本-フィンランド2国間セミナー「Future prospects of photosynthetic organisms : from genomes to environment」
    • Place of Presentation
      岡山ロイヤルホテル(岡山)(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 水分子酸化を可能とする光合成反応中心蛋白質の電子移動2011

    • Author(s)
      石北央
    • Organizer
      大阪大学蛋白質研究所セミナー「分子科学と生理学が解き明かす植物の光エネルギー変換の新展開」
    • Place of Presentation
      大阪大学蛋白質研究所(大阪)(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 水分子酸化を可能とする光合成系II内の電子移動2011

    • Author(s)
      石北央
    • Organizer
      日本物理学会 第66回年次大会
    • Place of Presentation
      新潟大学(新潟)(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Hydrogen bonding pattern controls the electron transfer energetics between quinones in photosynthetic reaction centers2010

    • Author(s)
      石北央
    • Organizer
      第48回日本生物物理学会年会
    • Place of Presentation
      東北大学(仙台)
    • Year and Date
      2010-09-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Analyzing protein bioenergetics using 3D structural information2010

    • Author(s)
      Hiroshi Ishikita
    • Organizer
      CBI学会2010年大会
    • Place of Presentation
      一橋記念講堂、東京(口頭発表)
    • Year and Date
      2010-09-15
    • Related Report
      2010 Final Research Report
  • [Presentation] Analyzing protein bioenergetics using 3D structural informati2010

    • Author(s)
      石北央
    • Organizer
      CBI学会2010年大会(Chem-Bio Informatics Society)
    • Place of Presentation
      学術総合センター(東京)
    • Year and Date
      2010-09-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Influence of the protein environment on the P680 redox potentials in Photosystem II2010

    • Author(s)
      H.Ishikita, E.-W.Knapp
    • Organizer
      the 15th International Congress of Photosynthesis
    • Place of Presentation
      北京(中国)
    • Year and Date
      2010-08-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Computational analysis of light-induced electron transfer reaction in proteins2010

    • Author(s)
      H.Ishikita
    • Organizer
      国際シンポジウム「光エネルギーと物質変換:人工光合成の未来」
    • Place of Presentation
      近畿大学(大阪府)
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Oxidation Power of the Chlorophyll Pair P680 in Photosystem II2010

    • Author(s)
      Hiroshi Ishikita
    • Organizer
      第70回分子科学国際研究会
    • Place of Presentation
      分子科学研究所、愛知
    • Related Report
      2010 Final Research Report
  • [Presentation] Frontiers in the Simulations of Macromolecules, Symposium in Honor of Arieh Warshel2010

    • Place of Presentation
      Los Angeles、USA
    • Related Report
      2010 Final Research Report
  • [Presentation]2010

    • Organizer
      15th International Congress on Photosynthesis
    • Place of Presentation
      北京、中国
    • Related Report
      2010 Final Research Report
  • [Presentation] Electron transfer in photosynthetic reaction centers2010

    • Author(s)
      Hiroshi Ishikita
    • Organizer
      Frontiers in the Simulations of Macromolecules, Symposium in Honor of Arieh Warshel
    • Place of Presentation
      Los Angeles(USA)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Oxidation Power of the Chlorophyll Pair P680 in Photosystem II2010

    • Author(s)
      石北央
    • Organizer
      第70回分子科学国際研究会
    • Place of Presentation
      分子科学研究所(愛知)(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Photosystem IIの蛋白質環境がどのようにしてクロロフィルペアP680の強力な酸化力を引き出しているか2009

    • Author(s)
      石北央
    • Organizer
      第47回日本生物物理学会年会
    • Place of Presentation
      アスティとくしま(徳島県)
    • Year and Date
      2009-11-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] 青色光受容体蛋白質AppA BLUFにおける水素結合パターン変化による電子移動制御2009

    • Author(s)
      石北央
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2009-10-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] Hydrogen bonding pattern controls the electron transfer energetics between quinones in photosynthetic reaction centers

    • Author(s)
      Hiroshi Ishikita
    • Organizer
      第48回日本生物物理学会年会
    • Place of Presentation
      東北大学、仙台(口頭発表)
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.cp.kyoto-u.ac.jp/Ishikita/index.htm

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.cp.kyoto-u.ac.jp/Ishikita/index.htm

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.cp.kyoto-u.ac.jp/Ishikita/index.htm

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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