| Project/Area Number |
21770169
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biophysics
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| Research Institution | Osaka University |
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Principal Investigator |
SAKURAI Kazumasa Osaka University, 蛋白質研究所, 助教 (10403015)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 蛋白質 / 生物物理 / 自己組織化 / アミロイド線維 / NMR |
|---|
| Research Abstract |
The purpose of this study is to clarify how β2-Microglobulin (β2m), associated with the dialysis-related amyloidosis, changes its conformation when the disease develops by using nuclear magnetic resonance. It has been believed that β2m forms amyloid fibril through a partially structured state. However, from the present data, we suggested that the partially structured state should be "activated" to be extensively unfolded state, in which the hydrophobic residues are exposed to associate with the seed.
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