Role of RNA-binding proteins in mitochondrial function

• Project/Area Number: 21770180
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Molecular biology
• Research Institution: University of Tsukuba
• Principal Investigator: NAIKI Takahiro University of Tsukuba, 大学院・人間総合科学研究科, 助教 (70420081)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: RNA結合タンパク質 / アポトーシス / mRNA安定性制御 / 細胞増殖

Research Abstract

RNA-binding proteins coordinate protein expression through post-transcriptional regulations. We demonstrated that hnRNPK localizes in Stress Granules and has a role for the regulation of ATP level during stress condition through RNA regulation. Furthermore, we revealed that RBM42, an hnRNPK binding protein, functions in the regulation of ATP synthesis. We also obtained evidences that hnRNPK and RBM42 coordinate cell proliferation by regulating novel target mRNAs.