Mechanisms of the piRNA biogenesis in germ line cells
| Project/Area Number |
21770191
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Molecular biology
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| Research Institution | Keio University |
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Principal Investigator |
SAITO Kuniaki Keio University, 医学部, 講師 (30423396)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 生殖 / 生合成 / piRNA / ショウジョウバエ / Piwi / レトロトランスポゾン / 卵巣 / 生殖細胞 / RNAi / 培養細胞 / 3'UTR |
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| Research Abstract |
piRNAs associating with Piwi family proteins are essential small RNAs for germ cell development. In this study, I investigated how piRNAs are produced in germ cells using Drosophila melanogaster as a model organism. As a result, I have identified novel piRNA biogenesis factors and characterized the molecular functions of them. Thus, this study will contribute to our understanding of the characters of germ line cells.
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Report
(3 results)
Research Products
(9 results)
