| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Research Abstract |
HSP play a center role in the stress response. The promoter of HSP gene exist HSE sequence, HSF protein binds to HSE and regulates transcription of HSP.
Mediator is a multiprotein complex that functions as a transcriptional coactivator. Mediator complex is required for the successful transcription of nearly all gene regulated RNA polymerase II in yeast.
In this study, we revealed that the necessity of mediator changed by the difference of HSE sequence.
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