| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
Gene amplification is involved in a variety of biological phenomena, including malignant progression, drug resistance, and gene evolution. However, details of the molecular mechanisms remain to be determined. Based on our findings of gene amplification system in yeast, we have obtained a clue to elucidate the mechanism for oncogene amplification. We also work on the construction of marker gene that sensitively detect the introduction of mutations involved in gene amplification.
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