| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
The small ubiquitin-like modifier (SUMO) conjugates transcription factors, and suppresses the transcription of their target genes. Although various SUMO-conjugated transcription factors have been isolated, mechanisms how sumoylated-transcription factors suppress transcription remain largely unknown. To understand mechanisms of SUMO-dependent transcriptional repression, we purified interacting partners for a nuclear receptor and identified ARIP4 known as a SNF2 chromatin-remodeling factor.
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