| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
We have found that the small GTPase RAB-11 is required for cortical granule exocytosis after fertilization which delivers essential extracellular matrices. Furthermore, GFP : : RAB-11 accumulates transiently on the cortical granules during ovulation. To understand how the localization and/or activity of RAB-11 are developmentally regulated, we looked for RAB-11-binding proteins by yeast two-hybrid screening. We identified a new RAB-11-binding protein named REI-1. REI-1 is highly conserved amang metazoans, implying its fundamental role.
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