A novel function of Jagged in the zebrafish lateral line development

• Project/Area Number: 21770201
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Cell biology
• Research Institution: University of Tsukuba
• Principal Investigator: MIZUNO Tomoaki University of Tsukuba, 大学院・人間総合科学研究科, 助教 (80529032)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: ゼブラフィッシュ / Notch

Research Abstract

We studied an anti-apoptotic role of Jagged1 using the zebrafish lateral line development as a model system. Jagged1 knockdown-induced apoptosis was suppressed by knockdown of p53 tumor suppressor. Expression of Six1 transcription factor was decreased in Jagged1 knockdown embryos. Similar to Jagged1, Six1 knockdown induced apoptosis. These results imply that p53 and Six1 are involved in regulation of anti-apoptosis via Jagged1.

Research Products

• [Journal Article] The Caenorhabditis elegans Ste20-Related Kinase and Rac-Type Small GTPase Regulate the c-Jun N-Terminal Kinase Signaling Pathway Mediating the Stress Response. (2010)
  • Author(s): Kota Fujiki, Tomoaki Mizuno, Naoki Hisamoto, Kunihiro Matsumoto
  • Journal Title: Molecular and Cellular Biology 30(4) Pages: 995-1003
  • Peer Reviewed
• [Journal Article] The Caenorhabditis elegans Ste20-Related Kinase and Rac-Type Small GTPase Regulate the c-Jun N-Terminal Kinase Signaling Pathway Mediating the Stress Response (2010)
  • Author(s): Fujiki K, Mizuno T, Hisamoto N, Matsumoto K.
  • Journal Title: Molecular and Cellular Biology 30 Pages: 995-1003
  • Peer Reviewed
• [Presentation] 線虫をモデル動物とした神経再生を誘導する因子/受容体の解析 (2010)
  • Author(s): 李春、久本直毅、水野智亮、松本邦弘
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸
• [Presentation] The C.elegans JNK signaling pathway regulates FOS-1 transcription factor in stress response (2010)
  • Author(s): Ayuna Hattori, Tomoaki Mizuno, Naoki Hisamoto, Kunihiro Matsumoto
  • Organizer: East Asia Worm Meeting
  • Place of Presentation: Tokyo, JAPAN
• [Presentation] 線虫JNKは転写因子Fosをリン酸化し負に制御する (2009)
  • Author(s): 服部鮎奈、水野智亮、久本直毅、松本邦弘
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] KGB-1, a JNK-like MAPK, negatively regulates FOS-1 transcription factor in stress response (2009)
  • Author(s): Ayuna Hattori, Tomoaki Mizuno, Naoki Hisamoto, Kunihiro Matsumoto
  • Organizer: International Worm Meeting
  • Place of Presentation: Los Angeles, USA
• [Presentation] C.elegans MLK-1 MAPKKK is regulated by double phosphorylation in JNK-mediated stress response pathway (2009)
  • Author(s): Kota Fujiki, Tomoaki Mizuno, Naoki Hisamoto, Kunihiro Matsumoto
  • Organizer: International Worm Meeting
  • Place of Presentation: Los Angeles, USA
• [Remarks] ホームページ等
  • URL: http://www.md.tsukuba.ac.jp/basic-med/molcellbiol/index.html