Identification and characterization of novel proteins regulating epithelial barrier functions

• Project/Area Number: 21770210
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Cell biology
• Research Institution: Kobe University
• Principal Investigator: IZUMI Yasushi Kobe University, 医学研究科, 助教 (10373268)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 遺伝学 / 遺伝子 / 昆虫 / 細胞・組織 / 発生・分化 / 上皮 / バリア機能 / ショウジョウバエ / 細胞接着 / セプテートジャンクション

Research Abstract

Septate junctions (SJs) are specialized intercellular junctions, which restrict the free diffusion of solutes through the paracellular route in invertebrate epithelia. Here, we identified a novel cell adhesion protein Mesh and found that this protein is essential for the formation of endoderm-specific SJs, smooth SJs and the intestinal barrier function in Drosophila midgut.

Research Products

• [Journal Article] Phosphorylation state regulates the localization of Scribble at adherens junctions and its association with E-cadherin-catenin complexes. (2011)
  • Author(s): Yoshihara K, Ikenouchi J, Izumi Y, Akashi M, Tsukita S, Furuse M.
  • Journal Title: Exp Cell Res. 317(4) Pages: 413-22
  • Peer Reviewed
• [Journal Article] Phosphorylation state regulates the localization of Scribble at adherens junctions and its association with E-cadher in-catenin complexes. (2011)
  • Author(s): Ken Yoshihara
  • Journal Title: Experimental Cell Research Volume: 317 Pages: 413-422
  • Peer Reviewed
• [Presentation] ショウジョウバエのスムースセプテートジャンクションに局在する新規細胞接着タンパク質の同定と機能解析 (2010)
  • Author(s): 泉裕士、柳橋祐一、古瀬幹夫
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: ポートピアホテル(神戸市)
  • Year and Date: 2010-12-07
• [Presentation] ショウジョウバエのスムースセプテートジャンクションに局在する新規細胞接着タンパク質の同定と機能解析 (2010)
  • Author(s): 泉裕士
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: ポートピアホテル(兵庫県)
  • Year and Date: 2010-12-07
• [Presentation] Identification and characterization of a novel smooth septate junction component (2009)
  • Author(s): 泉裕士、柳橋祐一、古瀬幹夫
  • Organizer: The 9^<th> Japanese Drosophila Research Conference
  • Place of Presentation: ヤマハリゾートつま恋(静岡県)
  • Year and Date: 2009-07-06
• [Remarks] ホームページ等
  • URL: http://www.med.kobe-u.ac.jp/cellb/
• [Remarks]
  • URL: http://www.med.kobe-u.ac.jp/cellb/
• [Remarks]
  • URL: http://www.med.kobe-u.ac.jp/cellb/