Identification and characterization of novel proteins regulating epithelial barrier functions
| Project/Area Number |
21770210
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | Kobe University |
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Principal Investigator |
IZUMI Yasushi Kobe University, 医学研究科, 助教 (10373268)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 遺伝学 / 遺伝子 / 昆虫 / 細胞・組織 / 発生・分化 / 上皮 / バリア機能 / ショウジョウバエ / 細胞接着 / セプテートジャンクション |
|---|
| Research Abstract |
Septate junctions (SJs) are specialized intercellular junctions, which restrict the free diffusion of solutes through the paracellular route in invertebrate epithelia. Here, we identified a novel cell adhesion protein Mesh and found that this protein is essential for the formation of endoderm-specific SJs, smooth SJs and the intestinal barrier function in Drosophila midgut.
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Report
(3 results)
Research Products
(8 results)
