Analysis of molecular mechanisms of the formation of the intercellular junction-underlying actin bundle using semi-intact epithelium.
| Project/Area Number |
21770212
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | Kobe University |
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Principal Investigator |
HIGASHI Tomohito Kobe University, 大学院・医学研究科, グローバルCOE研究員 (70515072)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 細胞間接着 / アクチン細胞骨格 / Rho低分子量Gタンパク質 / ArhGEF11 / 上皮細胞 / タイトジャンクション / RhoGEF / 裏打ちアクチン / RhoA |
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| Research Abstract |
Epithelial sheets play important roles in morphogenesis of multicellular organisms. So far, it has been unknown how the intercellular junction-underlying actin cytoskeleton are formed. In this study, I showed that ArhGEF11, a guanine nucleotide exchange factor of the small GTPase RhoA, is localized at the cell-cell-junction and that ArhGEF11 is required for the formation of the actin cytoskeleton vertical to cell-cell junction during the formation process of cell-cell junction.
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Report
(3 results)
Research Products
(6 results)
