Molecular organization of tricellular junction

• Project/Area Number: 21770213
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Cell biology
• Research Institution: Kobe University
• Principal Investigator: ODA Yukako Kobe University, 大学院・医学研究科, 助教 (70452498)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 上皮細胞 / 細胞間接着 / タイトジャンクション / トリセルラージャンクション / 細胞骨格 / アクチン / トリセルラータイトジャンクション / トリセルリン / 細胞接着

Research Abstract

In an epithelial layer, each cell forms polygonal structure to establish cell-cell adhesions with neighboring cells. We show that tricelluar junctional protein shapes epithelial cell morphology at the tricelluar corner, which leads to activation of the actin reorganization, thereby shaping the polygonal cell morphology.

Research Products

• [Journal Article] Angulin/LSR defines cell corners for tricellular tight junction formation in epithelial cells (2011)
  • Author(s): Masuda S, Oda Y, Sasaki H, Ikenouchi J, Higashi T, Akashi M, Nishi E, Furuse M
  • Journal Title: J.Cell.Sci. Volume: 124 Pages: 548-555
  • Peer Reviewed
• [Journal Article] Angulin/LSR defines cell corners for tricellular tight junction formation in epithelial cells. (2009)
  • Author(s): Masuda S, Oda Y, Sasaki H, Ikenouchi J, Higashi T, Akashi M, Nishi E, Furuse M.
  • Journal Title: J.Cell.Sci. 122 Pages: 985-94
  • Peer Reviewed
• [Journal Article] The E3 ubiquitin ligase LNX1p80 promotes the removal of claudins from tight junctions in MDCK cells. (2009)
  • Author(s): Takahashi S, Iwamoto N, Sasaki H, Ohashi M, Oda Y, Tsukita S, Furuse M.
  • Journal Title: J.Cell.Sci. 122 Pages: 985-94
  • Peer Reviewed
• [Journal Article] The E3 ubiquitin ligase LNXp80 promotes the removal of claudins from tight junctions in MDCK cells. (2009)
  • Author(s): Takahashi S, Iwamoto N, Sasaki H, Ohashi M, Oda Y, Tsukita S, Furuse M.
  • Journal Title: Journal of Cell Science 122 Pages: 985-994
  • Peer Reviewed
• [Presentation] Molecular organization of tricellular tight junctions (2010)
  • Author(s): 古瀬幹夫, 増田小百合, 小田裕香子
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: トリセルラータイトジャンクションの分子構築
  • Year and Date: 2010-12-08
• [Presentation] トリセルラータイトジャンクションの分子構築 (2010)
  • Author(s): 古瀬幹夫, 増田小百合, 小田裕香子
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会シンポジウム
  • Place of Presentation: 神戸ポートアイランド(兵庫県)(招待講演)
  • Year and Date: 2010-12-08
• [Presentation] Tricellulin regulates actin-myosin organization at tricellular contacts (2009)
  • Author(s): 小田裕香子, 池ノ内順一, 古瀬幹夫
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-10
• [Presentation] Tricellulin regulates actin-myosin organization at tricellular contacts (2009)
  • Author(s): 小田裕香子
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-12-10
• [Presentation] 3細胞接着部位における細胞骨格制御 (2009)
  • Author(s): 小田裕香子, 池ノ内順一, 増田小百合, 古瀬幹夫
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: シンポジウム(招待講演)
  • Year and Date: 2009-10-24
• [Presentation] 3細胞接着部位における細胞骨格制御 (2009)
  • Author(s): 小田裕香子
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸国際会議場(兵庫県)
  • Year and Date: 2009-10-24
• [Presentation] Actin-Myosin Organization at Tricellular Contacts (2009)
  • Author(s): Yukako Oda, Junichi Ikuenouchi, Mikio Furuse.
  • Organizer: ASCB/JSCB/RIKEN CDB Summer Meeting
  • Place of Presentation: Kyoto (Japan)
• [Presentation] Actin-Myosin Organization at Tricellular Contacts (2009)
  • Author(s): 小田裕香子
  • Organizer: ASCB/JSCB/RIKEN CDB Summer Meeting
  • Place of Presentation: 京都国際会議場(京都府)
• [Remarks] ホームページ等
  • URL: http://www.med.kobe-u.ac.jp/cellb/
• [Remarks]
  • URL: http://www.med.kobe-u.ac.jp/cellb/
• [Remarks]
  • URL: http://www.med.kobe-u.ac.jp/cellb/