Ubiquitin signaling in Golgi biogenesi s

• Project/Area Number: 21770216
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Cell biology
• Research Institution: Kyushu University
• Principal Investigator: TOTSUKAWA Go Kyushu University, 医学研究院, 助教 (90399684)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 細胞構造 / 機能 / ゴルジ体 / オルガネラ / 形態形成 / ユビキチン

Research Abstract

A novel VCIP135 binding protein is identified, and named as p87. p87 localizes to the Golgi, and works as an essential factor for Golgi assembly. It is suggested that ubiquitin signaling mediated by VCIP135/p87 plays an important role in Golgi biogenesis, especially in mitosis.

Research Products

• [Journal Article] Phosphorylation of p37 isimportant for Golgi disassembly at mitosis. (2010)
  • Author(s): Kaneko, Y., Tamura, K., Totsukawa, G., Kondo, H.
  • Journal Title: Biochem Biophys Res Commun 402 Pages: 37-41
  • Peer Reviewed
• [Journal Article] Isolation of a point-mutated p47 lacking binding affinity to p97ATPase. (2010)
  • Author(s): Kaneko, Y., Tamura, K., Totsukawa, G., Kondo, H.
  • Journal Title: FEBS Lett 584 Pages: 3873-3877
  • Peer Reviewed
• [Journal Article] Phosphorylation of p37 is important for Golgi disassembly at mitosis. (2010)
  • Author(s): Kaneko, Y., Tamura, K., Totsukawa G., Kondo, H.
  • Journal Title: Biochem Biophys Res Commun Volume: 402 Pages: 37-41
  • Peer Reviewed
• [Journal Article] Isolation of a point-mutated p47 lacking binding affinity to p97ATPase. (2010)
  • Author(s): Kaneko, Y., Tamura, K., Totsukawa, G., Kondo, H.
  • Journal Title: FEBS Lett Volume: 584 Pages: 3873-3877
  • Peer Reviewed