Metabolicmachineryandbiologicalfunctionofmembransphingolipids
| Project/Area Number |
21770217
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Cell biology
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
MOTOHIRO Tani 九州大学, 理学研究院, 准教授 (20452740)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 生体膜 / スフィンゴ脂質 / リン脂質 / 脂質代謝酵素 |
|---|
| Research Abstract |
Sphingolipids, the major lipid components of the eukaryotic plasma membrane, playcritical roles in many physiologically important events. In this study, we fbcused onsphingolipid-metabolizing enzymes and investigated physiological function of membrane complex sphingolipids and ceramides by using the yeast Saochazomyces cerevisiae as a model organism. The results were summarized below :[ 1] impairment of metabolism of aspecific subtype of complex sphingolipid, phosphoinositides, and phosphatidylserine causessynthetic lethal phenotype,[ 2] specific complex sphingolipid and phosphatidylserine arecoordinately involved in vesicular trafficking between early endosomes and the Golgi compartments,[ 3] hydroxylation states and chain lengths of fatty acids in ceramide arecritical structural factors fbr toxicity of ceramide.
|
Report
(4 results)
Research Products
(42 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Mechanistic insights into the hydrolysis and synthesis of ceramide by neutral ceramidase.2009
Author(s)
T. Inoue, N. Okino, Y. Kakuta, A. Hijikata, H. Okano, H. M. Goda, M. Tani, N. Sueyoshi, K. Kambayashi, H. Matsumura, Y. Kai, M. Ito
-
Journal Title
Journal of Biological Chemistry 284
Pages: 9566-9577
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
