| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Research Abstract |
Sphingolipids, the major lipid components of the eukaryotic plasma membrane, playcritical roles in many physiologically important events. In this study, we fbcused onsphingolipid-metabolizing enzymes and investigated physiological function of membrane complex sphingolipids and ceramides by using the yeast Saochazomyces cerevisiae as a model organism. The results were summarized below :[ 1] impairment of metabolism of aspecific subtype of complex sphingolipid, phosphoinositides, and phosphatidylserine causessynthetic lethal phenotype,[ 2] specific complex sphingolipid and phosphatidylserine arecoordinately involved in vesicular trafficking between early endosomes and the Golgi compartments,[ 3] hydroxylation states and chain lengths of fatty acids in ceramide arecritical structural factors fbr toxicity of ceramide.
|
