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Role of PFR cells during digit identity determination.

Research Project

Project/Area Number 21770226
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Developmental biology
Research InstitutionTohoku University

Principal Investigator

SUZUKI Takayuki  Tohoku University, 加齢医学研究所, 助教 (40451629)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords指の個性 / 骨 / BMP / PFR / 指間部 / ニワトリ / 分子生物学 / 発生生物学
Research Abstract

We found that the cells located distal to the digital lay received positional information from interdigit. These cells get BMP signaling from adjacent interdigit located at the posterior side. I named this region 'PFR'. We found that digit identity is controlled by physical flow in the interdigit, and this conclusion brings us new insight how morphogen gradient works in the embryos. Further, we identified single point mutation in Silkie chicken that causes preaxial polydactyly in the leg. We will publish this data in this May, in press now

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (14 results)

All 2011 2010 2009 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (7 results) Remarks (3 results)

  • [Journal Article] Identification of spontaneous mutations within the long-range limb-specific Sonic Hedgehog enhancer (ZRS) that alter Sonic Hedgehog expression in the chicken limb mutants oligozeugodactly and Silkie Breed.2011

    • Author(s)
      Maas S.A., Suzuki T., Fallon J.F.
    • Journal Title

      Dev.Dyn. in press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Spontaneous Mutations Within the Long-Range Limb-Specific Sonic Hedgehog Enhancer (ZRS) That Alter Sonic Hedgehog Expression in the Chicken Limb Mutants oligozeugodactyly and Silkie Breed2011

    • Author(s)
      Sarah A.Maas, Takayuki Suzuki, John F.Fallon
    • Journal Title

      Developmental Dynamics

      Volume: 240 Pages: 1212-1222

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a primary target of thalidomide teratogenicity.2010

    • Author(s)
      Ito T, Ando H, Suzuki T, Ogura T, Hotta K, Imamura Y, Yamaguchi Y, Handa H.
    • Journal Title

      Science. 327

      Pages: 1345-1350

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a primary target of thalidomide teratogenicity2010

    • Author(s)
      Ito T, Ando H, Suzuki T, Ogura T, Hotta K, Imamura Y, Yamaguchi Y, Handa H.
    • Journal Title

      Science 327

      Pages: 1345-1350

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 四肢発生をモデルとした形態形成のロジックを解明するための定量的アプローチ2010

    • Author(s)
      鈴木孝幸
    • Organizer
      定量生物の会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Quantification of dynamic morphogen activity in the developing chick limb bud2010

    • Author(s)
      Takayuki Suzuki
    • Organizer
      11th International Conference on Limb Development and Regeneration
    • Place of Presentation
      College of William and Maly(アメリカ)
    • Year and Date
      2010-07-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] Quantification of Morphogen activity in the Developing chick limb bud2010

    • Author(s)
      Takayuki Suzuki
    • Organizer
      第43回日本発生生物学会
    • Place of Presentation
      京都
    • Year and Date
      2010-06-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] モルフォゲンの活性を発光顕微鏡を用いて可視化する2009

    • Author(s)
      Takayuki Suzuki
    • Organizer
      第32回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-10
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 肢芽の発生における位置情報を定量的に解析する2009

    • Author(s)
      Takayuki Suzuki
    • Organizer
      日本発生生物学会秋期シンポジウム
    • Place of Presentation
      三島
    • Year and Date
      2009-11-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Molecular profile and functional role of the PFR to specify each digit identity2009

    • Author(s)
      Takayuki Suzuki
    • Organizer
      第16回国際発生生物学会
    • Place of Presentation
      エジンバラ(イギリス)
    • Year and Date
      2009-09-07
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Role of GDF11 during hindlimb field determination2009

    • Author(s)
      Takayuki Suzuki
    • Organizer
      第42回日本発生生物学会
    • Place of Presentation
      新潟
    • Year and Date
      2009-05-28
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://web.me.com/stakayuki77/Takayuki/Takayuki_Suzuki.htmll

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://web.me.com/stakayuki77/Takayuki/Takayuki_Suzuki.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://web.me.com/stakayuki77/Ogura_lab/Top.html

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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