| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
The primary goal of this research project is to understand how the neurogenic ectoderm of the sea urchin embryo establishes the resistant mechanisms against signals that induce non-neurogenic ectoderms. With microarray experiments using FoxQ2 morphants, in situ hybridization, and QPCR analyses, Fez was identified as a downstream factor of FoxQ2 function in the neurogenic ectoderm. When Fez function was blocked, the size of neurogenic ectoderm became smaller than that of normal embryos. However, that size decrease was rescued by simply blocking BMP2/4 function that induces non-neurogenic ectoderm. This indicates that FoxQ2 induces Fez to block the non-neurogenic ectoderm-inducing signal to maintain the size of neurogenic ectoderm of the sea urchin embryos.
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