| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
During the neocortical development, neural precursor cells are located in the ventricular zone by attaching their apical process to the ventricular surface through cadherin-based adherens junctions and form a pseudostratified epithelial structure. Once these cells commit to become neurons or intermediate neuronal progenitors, they delaminate and start migration toward the pial surface. However, it has remained unclear how the detachment from the neuroepithelium, the first step of radial migration, is coordinated with neuronal fate commitment. This study revealed a mechanism that links these two processes.
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