• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Dissecting cell competition focused on the output switching of JNK signaling

Research Project

Project/Area Number 21770233
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Developmental biology
Research InstitutionKobe University

Principal Investigator

OHSASWA Shizue  Kobe University, 大学院・医学研究科, グローバルCOE研究員 (80515065)

Research Collaborator IGAKI Tatsushi  神戸大学, 大学院・医学研究科, 特命准教授 (00467648)
Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords細胞競合 / 細胞間コミュニケーション / がん抑制 / 癌抑制
Research Abstract

A newly emerged oncogenic cell in the epithelium has to confront anti-tumor selective pressures in the host tissue. However, the underlying mechanism is poorly understood. Using Drosophila model system, we found that normal epithelial cells activate JNK signaling through "cell competition" in response to the emergence of oncogenic polarity-deficient cells, which activates phagocytic pathway, thereby eliminating oncogenic neighbors by engulfment.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (30 results)

All 2011 2010 2009 Other

All Journal Article (7 results) (of which Peer Reviewed: 5 results) Presentation (22 results) Remarks (1 results)

  • [Journal Article] Elimination of oncogenic neighbors by JNK-mediated engulfment in Drosophila2011

    • Author(s)
      Ohsawa S, Sugimura K, Takino K, Xu T, Miyawaki A, Igaki T
    • Journal Title

      Developmental Cell 15

      Pages: 315-328

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Elimination of oncogenic neighbors by JNK-mediated engulfment in Drosophila2011

    • Author(s)
      Ohsawa S, Sugimura K, Takino K, Xu T, Miyawaki A, Igaki T
    • Journal Title

      Developmental Cell

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activity2010

    • Author(s)
      Ohsawa S, Hamada S, Kuida K, Yoshida H, Igaki T, Miura M
    • Journal Title

      Proc.Natl.Acad.Sci.USA. 107

      Pages: 13366-13371

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 状況依存的細胞死シグナル制御による上皮のがん抑制2010

    • Author(s)
      大澤志津江、井垣達吏
    • Journal Title

      実験医学増刊 28

      Pages: 129-134

    • Related Report
      2010 Final Research Report
  • [Journal Article] Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activity2010

    • Author(s)
      Ohsawa S, Hamada S, Kuida K, Yoshida H, Igaki T, Miura M
    • Journal Title

      Proc.Natl.Acad.Sci.USA.

      Volume: 107 Pages: 13366-13371

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 状況依存的細胞死シグナル制御による上皮のがん抑制2010

    • Author(s)
      大澤志津江、井垣達吏
    • Journal Title

      実験医学増刊

      Volume: 28 Pages: 129-134

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Caspase-9 activation revealed by semaphorin 7A cleavage is independent of apoptosis in the aged olfactory bulb2009

    • Author(s)
      Ohsawa S, et al
    • Journal Title

      Journal of Neuroscience 29

      Pages: 11385-11392

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Genetic screen in Drosophila for tumor growth and malignancy2010

    • Author(s)
      Nakamura M, Ohsawa S, Sato Y, Nagao A, Igaki T
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会(口頭発表)
    • Place of Presentation
      神戸ポートアイランド(神戸)
    • Year and Date
      2010-12-09
    • Related Report
      2010 Final Research Report
  • [Presentation] RNA processing defects cooperate with oncogenic Ras to stimulate non-cell autonomous tumor growth in Drosophila2010

    • Author(s)
      Enomoto M, Sato Y, Nakamura M, Ohsawa S, Igaki T
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会(ポスター発表)
    • Place of Presentation
      神戸ポートアイランド(神戸)
    • Year and Date
      2010-12-09
    • Related Report
      2010 Final Research Report
  • [Presentation] Analyzing cell competition during normal development in Drosophila2010

    • Author(s)
      Takino K, Ohsawa S, Igaki T
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会(ポスター発表)
    • Place of Presentation
      神戸ポートアイランド(神戸)
    • Year and Date
      2010-12-09
    • Related Report
      2010 Final Research Report
  • [Presentation] Genetic screen for genes that regulate cell competition2010

    • Author(s)
      Kizawa D, Ohsawa S, Takino K, Enomoto M, Igaki T
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会(ポスター発表)
    • Place of Presentation
      神戸ポートアイランド(神戸)
    • Year and Date
      2010-12-09
    • Related Report
      2010 Final Research Report
  • [Presentation] RNA processing defects cooperate with oncogenic Ras to stimulate non-cell autonomous tumor growth in Drosophila2010

    • Author(s)
      Enomoto M, Sato Y, Nakamura M, Ohsawa S, Igaki T
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Analyzing cell competition during normal development in Drosophila2010

    • Author(s)
      Takino K, Ohsawa S, Igaki T
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Genetic screen for genes that regulate cell competition2010

    • Author(s)
      Kizawa D, Ohsawa S, Takino K, Enomoto M, Igaki T
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Genetic analysis of tumor progression caused by dysregulation of the endocytic machinery2010

    • Author(s)
      Kanemoto Y, Ohsawa S, Igaki T
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会(口頭発表)
    • Place of Presentation
      神戸ポートアイランド(神戸)
    • Year and Date
      2010-12-07
    • Related Report
      2010 Final Research Report
  • [Presentation] Genetic analysis of tumor progression caused by dysregulation of the endocytic machinery2010

    • Author(s)
      Kanemoto Y, Oheawa S, Igaki T
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Genetic screen in Drosophila for tumor growth and malignancy2010

    • Author(s)
      Nakamura M, Ohsawa S, Sato Y, Nagao A, Igaki T
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Elimination of oncogenic neighbors by JNK-mediated super-competition2010

    • Author(s)
      Ohsawa S, Sugimura K, Takino K, Xu T, Miyawaki A, Igaki T
    • Organizer
      51^<st> Drosophila Research Conference(口頭発表)
    • Place of Presentation
      アメリカ・ワシントンDC
    • Year and Date
      2010-04-09
    • Related Report
      2010 Final Research Report
  • [Presentation] Elimination of oncogenic neighbors by JNK-mediated super-competition2010

    • Author(s)
      Ohsawa S, Sugimura K, Takino K, Xu T, Miyawaki A, Igaki T
    • Organizer
      51^<st> Drosophila Research Conference
    • Place of Presentation
      ワシントンDC(米国)
    • Year and Date
      2010-04-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Genetic analysis of cell-elimination that regulates intrinsic tumor suppression and epithelial maintenance in Drosophila2010

    • Author(s)
      Ohsawa S, Sugimura K, Takino K, Xu T, Miyawaki A, Igaki T
    • Organizer
      The 16^<th> International Conference of the ISD(ポスター発表)
    • Place of Presentation
      奈良県新公会堂(奈良)
    • Related Report
      2010 Final Research Report
  • [Presentation] Genetic analysis of tumor progression caused by dysregulation of the endocytic machinery2010

    • Author(s)
      Igaki T, Kanemoto Y, Ohsawa S
    • Organizer
      The 16^<th> International Conference of the ISD(ポスター発表)
    • Place of Presentation
      奈良県新公会堂(奈良)
    • Related Report
      2010 Final Research Report
  • [Presentation] Genetic analysis of cell-elimination that regulates intrinsic tumor suppression and epithelial maintenance in Drosophila2010

    • Author(s)
      Ohsawa S, Takino K, Igaki T
    • Organizer
      第43回日本発生生物学会年会(ポスター発表)
    • Place of Presentation
      国立京都国際会議場(京都)
    • Related Report
      2010 Final Research Report
  • [Presentation] A non-cell autonomous genetic screen for identifying regulators of cell competition2010

    • Author(s)
      Takino K, Ohsawa S, Igaki T
    • Organizer
      第43回日本発生生物学会年会(ポスター発表)
    • Place of Presentation
      国立京都国際会議場(京都)
    • Related Report
      2010 Final Research Report
  • [Presentation] Genetic analysis of cell-elimination that regulates intrinsic tumor suppression and epithelial maintenance in Drosophila2010

    • Author(s)
      Ohsawa S, Sugimura K, Takino K, Xu T, Miyawaki A, Igaki T
    • Organizer
      The 16^<th> International Conference of the ISD
    • Place of Presentation
      奈良県新公会堂(奈良県)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Genetic analysis of tumor progression caused by dysregulation of the endocytic machinery2010

    • Author(s)
      Igaki T, Kanemoto Y, Ohsawa S
    • Organizer
      The 16^<th> International Conference of the ISD
    • Place of Presentation
      奈良県新公会堂(奈良県)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Genetic analysis of cell-elimination that regulates intrinsic tumor suppression and epithelial maintenance in Drosophila2010

    • Author(s)
      Ohsawa S, Takino K, Igaki T
    • Organizer
      第43回日本発生生物学会年会
    • Place of Presentation
      国立京都国際会議場(京都府)
    • Related Report
      2010 Annual Research Report
  • [Presentation] A non-cell autonomous genetic screen for identifying regulators of cell competition2010

    • Author(s)
      Takino K, Ohsawa S, Igaki T
    • Organizer
      第43回日本発生生物学会年会
    • Place of Presentation
      国立京都国際会議場(京都府)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Elimination of oncogenic neighbors by JNK-mediated super competition in Drosophila epithelium2009

    • Author(s)
      Ohsawa S, et al
    • Organizer
      第9回日本ショウジョウバエ研究会(JDRC9)
    • Place of Presentation
      ヤマハリゾートつま恋(静岡県)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Elimination of oncogenic neighbors by JNK-mediated super competition in Drosophila epithelium2009

    • Author(s)
      Ohsawa S, et al
    • Organizer
      ASCB/JSCB/RIKEN CDB 2009 meeting "Building the body Plan ; How Cell Adhesion, Signalling and Cytoskeletal Regulation Shape Morphogenesis"
    • Place of Presentation
      京都国際会議場(京都府)
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.med.kobe-u.ac.jp/igalab/index.html

    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi