Analysis of cis-regulatory evolution for the paralogous genes and failsafe networks

• Project/Area Number: 21770234
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Developmental biology
• Research Institution: Nara Institute of Science and Technology
• Principal Investigator: OCHI Haruki 奈良先端科学技術大学院大学, バイオサイエンス研究科, 特任助教 (00505787)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 遺伝子発現調節 / ゲノム / 遺伝子 / 発現制御 / 発生分化 / 比較ゲノム / 進化 / 発生・文化 / パラログ遺伝子 / Pax2 / Pax5 / Pax8 / Xenopus tropicalis / シス調節エレメント / Conserved non-coding element / ロバストネス / フェイルセーフ / 遺伝子ネットワーク

Research Abstract

We have studied regulatory mechanisms of vertebrate Pax2, Pax5 and Pax5 genes, which have evolved from a single ancestral gene of early cephalochordates. It is known that the three Pax genes exhibit distinct but overlapping expression during the ear, brain and kidney development, and interact each other in the co-expressed tissues. We compared human, chicken and Xenopus genomic sequences and identified 55 conserved noncoding sequences(CNSs) for Pax2, 19 for Pax5 and 6 for Pax8. We subjected the CNSs to the high-throughput co-transgenesis assay in Xenopus, identified 13 active kidney enhancers for Pax2. We also identified the one of the Pax2 kidney enhancers is activated in response to reduction of paralogous genes.

Research Products

• [Journal Article] Transcription factors involved in lens development from the preplacodal ectoderm (2012)
  • Author(s): Ogino H., Ochi H., Reza HM. And Yasuda K.
  • Journal Title: Developmental Biology Volume: 363 Pages: 333-47
  • Peer Reviewed
• [Journal Article] Evolution of a tissue-specific silencer underlies divergence in the expression of Pax2 and Pax8 (2012)
  • Author(s): Ochi H., Tamai T., Nagano H., Kawaguchi A., Sudou N., Ogino H.
  • Journal Title: Nature Communications Volume: (電子雑誌)(in press)
  • Peer Reviewed
• [Journal Article] Photoporation of biomolecules into single cells in living vertebrate embryos induced by a femtosecond laser amplifier (2011)
  • Author(s): Hosokawa Y., Ochi H., Iino T., Hiraoka A., Tanaka M.
  • Journal Title: PLoS ONE Volume: 6(11)
  • Peer Reviewed
• [Journal Article] Different requirement for Wnt/β-catenin signaling in limb regeneration of larval and adult Xenopus (2011)
  • Author(s): Yokoyama, H., Maruoka, T., Ochi, H., Aruga, A., Ohgo, S., Ogino, H. and Tamura, K.
  • Journal Title: PLoS ONE Volume: 6(7)
  • Peer Reviewed
• [Journal Article] Different requirement for Wnt/β-catenin signaling in limb regeneration of larval and adult Xenopus (2011)
  • Author(s): Yokoyama, H., Maruoka, T., Ochi, H., Aruga, A., Ohgo, S., Ogino H., Tamura, K.
  • Journal Title: PLoS ONE Volume: 6(7)
  • Peer Reviewed
• [Journal Article] Conserved expression of mouse Six1 in the pre-placodal region(PPR) and identification of an enhancer for the rostral PPR (2010)
  • Author(s): Sato S., Ikeda K., Shioi G., Ochi H., Ogino H., Yajima H. and Kawakami K.
  • Journal Title: Developmental Biology Volume: 344(1) Pages: 158-171
  • Peer Reviewed
• [Journal Article] Conserved expression of mouse Six1 in the pre-placodal region (PPR) and identification of an enhancer for the rostral PPR (2010)
  • Author(s): Sato, Shigeru
  • Journal Title: Developmental Biology Volume: 344 Pages: 158-171
  • Peer Reviewed
• [Journal Article] Evolution of a tissue-specific silencer underlies divergence in the expression of Pax2 and Pax8
  • Author(s): Ochi H., Tamai T., Nagano H., Kawaguchi A., Sudou N. And Ogino H.
  • Journal Title: Nature Communications Volume: 3 Pages: 848-848
  • Peer Reviewed
• [Presentation] Conservation and diversification of cis-regulatory mechanisms for pax2/5/8 paralog group in chordates (2011)
  • Author(s): Ochi H., Tamai T., Nagano H., Kawaguch A., Sudou N. and Ogino H.
  • Organizer: The American Society for Cell Biology(ASCB) Annual Meeting
  • Place of Presentation: Denver, Colorado, USA
  • Year and Date: 2011-12-04
• [Presentation] Conservation and diversification of cis-regulatory mechanisms for pax2/5/8 paralog group in chordates (2011)
  • Author(s): Ochi H., Tamai T., Nagano H., Kawaguch A., Sudou N., Ogino H.
  • Organizer: The American Society for Cell Biology (ASCB) Annual Meeting
  • Place of Presentation: Denver, Colorado, USA
  • Year and Date: 2011-12-04
• [Presentation] 組織特異的サイレンサーの獲得によるパラログ遺伝子の発現の多様化 (2011)
  • Author(s): 越智陽城、玉井智子、長野紘樹、川口茜、須藤則広、荻野肇
  • Organizer: 第5回日本ツメガエル研究集会
  • Place of Presentation: 静岡
  • Year and Date: 2011-10-06
• [Presentation] 両生類における皮膚の完全再生.四肢再生の基盤として- (2011)
  • Author(s): 横山仁、丸岡玉枝、越智陽城、有賀章郎、天野孝紀、城石俊彦、荻野肇、田村宏治
  • Organizer: 第5回日本ツメガエル研究集会
  • Place of Presentation: 静岡
  • Year and Date: 2011-10-06
• [Presentation] ツメガエルの初期発生におけるヒストンH3メチル化因子と脱メチル化因子の機能解析 (2011)
  • Author(s): 川口茜、越智陽城、須藤則広、荻野肇
  • Organizer: 第5回日本ツメガエル研究集会
  • Place of Presentation: 静岡
  • Year and Date: 2011-10-06
• [Presentation] エピジェネティック因子Jmjd3による異所的な細胞分化と器官形成の促進 (2011)
  • Author(s): 須藤則広、川口茜、越智陽城、荻野肇
  • Organizer: 第5回日本ツメガエル研究集会
  • Place of Presentation: 静岡
  • Year and Date: 2011-10-06
• [Presentation] 組織特異的サイレンサーの獲得によるパラログ遺伝子の発現の多様化 (2011)
  • Author(s): 越智陽城、玉井智子、長野紘樹、川口茜、須藤則広、荻野肇
  • Organizer: 第5回日本ツメガエル研究集会
  • Place of Presentation: 静岡、熱海市
  • Year and Date: 2011-10-06
• [Presentation] 両生類における皮膚の完全再生-四肢再生の基盤として- (2011)
  • Author(s): 横山仁、丸岡玉枝、越智陽城、有賀章郎、天野孝紀、城石俊彦、荻野肇、田村宏治
  • Organizer: 第5回日本ツメガエル研究集会
  • Place of Presentation: 静岡、熱海市
  • Year and Date: 2011-10-06
• [Presentation] ツメガエルの初期発生におけるヒストンH3メチル化因子と脱メチル化因子の機能解析 (2011)
  • Author(s): 川口茜、越智陽城、須藤則広、荻野肇
  • Organizer: 第5回日本ツメガエル研究集会
  • Place of Presentation: 静岡、熱海市
  • Year and Date: 2011-10-06
• [Presentation] エピジェネティック因子Jmjd3による異所的な細胞分化と器官形成の促准 (2011)
  • Author(s): 須藤則広、川口茜、越智陽城、荻野肇
  • Organizer: 第5回日本ツメガエル研究集会
  • Place of Presentation: 静岡、熱海市
  • Year and Date: 2011-10-06
• [Presentation] Heterochronic shift of Six1 expression drives evolutionary transition of vertebrate primary sensory neurons (2011)
  • Author(s): Yajima H., Suzuki M., Ochi H., Ikeda K., Sato S., Ogino H., Ueno N. and Kawakami K.
  • Organizer: 第44回日本発生生物学学会
  • Place of Presentation: 沖縄
  • Year and Date: 2011-05-20
• [Presentation] A pair of duplicated enhancers controls both a fail-safe regulation for development and adaptation to environmental stress (2011)
  • Author(s): Ochi H., Uchiyama C., Kawaguchi A., Tamai T. and Ogino H.
  • Organizer: 第44回日本発生生物学学会
  • Place of Presentation: 沖縄
  • Year and Date: 2011-05-20
• [Presentation] Heterochronic shift of Six1 expression drives evolutionary transition of vertebrate primary sensory neurons (2011)
  • Author(s): Yajima H., Suzuki M., Ochi H., Ikeda K., Sato S., Ogino H., Ueno N., Kawakami K.
  • Organizer: 第44回日本発生生物学学会
  • Place of Presentation: 沖縄、うるま市
  • Year and Date: 2011-05-20
• [Presentation] A H3K27 demethylase, Jmjd3, is essential for Xenopus eye development (2011)
  • Author(s): Kawaguchi A., Ochi H., Sudou N., Ogino H.
  • Organizer: 第44回日本発生生物学学会
  • Place of Presentation: 沖縄、うるま市
  • Year and Date: 2011-05-20
• [Presentation] A pair of duplicated enhancers controls both a fail-safe regulation for development and adaptation to environmental stress (2011)
  • Author(s): Ochi H., Uchiyama C, Kawaguchi A., Tamai T., Ogino H.
  • Organizer: 第44回日本発生生物学学会
  • Place of Presentation: 沖縄、うるま市
  • Year and Date: 2011-05-20
• [Presentation] A H3K27 demethylase, Jmjd3, is essential for Xenopus eye development (2011)
  • Author(s): Kawaguchi A., Ochi H., Sudou N. and Ogino H.
  • Organizer: 第44回日本発生生物学学会
  • Place of Presentation: 沖縄
  • Year and Date: 2011-05-19
• [Presentation] Morphological and Molecular Basis of Pelvic Fin Muscle Development in Zebrafish (2011)
  • Author(s): Yusuke Kikuchi
  • Organizer: The 20th CDB Meeting Molecular Bases for Evolution of Complex Traits
  • Place of Presentation: 理研CDB(神戸市)
  • Year and Date: 2011-02-23
• [Presentation] "Molecular and Cellular basis of Regeneration and Tissue Repair "Different involvement of Wnt/β-catenin signaling in limb regeneration of larval and adult Xenopus (2011)
  • Author(s): Yokoyama H., Maruoka T., Ochi H., Aruga A., Ohgo S., Ogino H. and Tamura K.
  • Organizer: EMBO Conference Series(3rd)
  • Place of Presentation: Portugal
• [Presentation] Morphological and Molecular Basis of Pelvic Fin Muscle Development in Zebrafish (2011)
  • Author(s): Kikuchi Y., Nakatani Y., Ochi H. and Tanaka M.
  • Organizer: The 20th CDB Meeting Molecular Bases for Evolution of Complex Traits
  • Place of Presentation: 神戸
• [Presentation] Conservation and neofunctionalization of cis-regulatory elements in paralog evolution (2010)
  • Author(s): Ogino H., Ochi H. and Uchiyama C.
  • Organizer: 第33回日本分子生物学会年会第83回日本生化学会大会合同大会
  • Place of Presentation: 兵庫
  • Year and Date: 2010-12-09
• [Presentation] Conservation and neofunctionalization of cis-regulatory elements in paralog evolution (2010)
  • Author(s): 荻野肇
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県神戸市)
  • Year and Date: 2010-12-09
• [Presentation] Evolutionary divergence and conservation of cis-regulatory elements in paralog formation (2010)
  • Author(s): 越智陽城
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県神戸市)
  • Year and Date: 2010-12-09
• [Presentation] Functional analysis of the histone H3K27 methyltransferase and demethylase in Xenopus embryonic development (2010)
  • Author(s): 川口茜
  • Organizer: The 16th International Conference of the International Society of Differentiation
  • Place of Presentation: 奈良県新公会堂(奈良市)
  • Year and Date: 2010-11-16
• [Presentation] Evolution of a fail-safe regulatory system for kidney development (2010)
  • Author(s): 越智陽城
  • Organizer: The 16th International Conference of the International Society of Differentiation
  • Place of Presentation: 奈良県新公会堂(奈良市)
  • Year and Date: 2010-11-15
• [Presentation] 田中幹子再生増幅フェムト秒チタンサファイアレーザーを利用した動物胚中の1細胞へのDNA・RNAの導 (2010)
  • Author(s): 細川陽一郎、越智陽城
  • Organizer: 第31回日本レーザー医学学会
  • Place of Presentation: 愛知学院大学
  • Year and Date: 2010-11-13
• [Presentation] 再生増幅フェムト秒チタンサファイアレーザーを利用した動物胚中の1細胞へのDNA・RNAの導入 (2010)
  • Author(s): 細川陽一郎
  • Organizer: 第31回日本レーザー医学会総会
  • Place of Presentation: ウインクあいち(愛知県)
  • Year and Date: 2010-11-13
• [Presentation] Evolution of a fail-safe regulatory system after genome duplications in chordates (2010)
  • Author(s): 荻野肇
  • Organizer: NAIST Global COE International Symposium 2010
  • Place of Presentation: 奈良先端科学技術大学院大学(奈良県生駒市)
  • Year and Date: 2010-11-11
• [Presentation] Mechanisms leading to determination of the embryonic eye (2010)
  • Author(s): Grainger, Robert, M.
  • Organizer: 13th International Xenopus Conference
  • Place of Presentation: Chateau Lake Louise(カナダ、Lake Louise)
  • Year and Date: 2010-09-16
• [Presentation] 田中幹子フェムト秒レーザー誘起衝撃力によるゼブラフィッシュ胚への生体分子導入 (2010)
  • Author(s): 細川陽一郎、越智陽城、飯野敬矩、平岡章宏
  • Organizer: 第71回応用物理学会学術講演会
  • Place of Presentation: 長崎大学
  • Year and Date: 2010-09-15
• [Presentation] フェムト秒レーザー誘起衝撃力によるゼブラフィッシュ胚への生体分子導入 (2010)
  • Author(s): 細川陽一郎
  • Organizer: 第71回応用物理学会学術講演会
  • Place of Presentation: 長崎大学(長崎市)
  • Year and Date: 2010-09-15
• [Presentation] 幼生期と成体期のXenopusでみられる四肢再生における異なる開始機構 (2010)
  • Author(s): 横山仁
  • Organizer: 平成22年度動物学会東北支部大会
  • Place of Presentation: 福島県立医科大学(福島市)
  • Year and Date: 2010-08-07
• [Presentation] パラログ形成にともなうシス調節機構の進化 (2010)
  • Author(s): 荻野肇、越智陽城
  • Organizer: 第12回日本進化学会大会
  • Place of Presentation: 東京工業大学
  • Year and Date: 2010-08-05
• [Presentation] パラログ形成にともなうシス調節機構の進化 (2010)
  • Author(s): 荻野肇
  • Organizer: 第12回日本進化学会大会
  • Place of Presentation: 東京工業大学(東京都)
  • Year and Date: 2010-08-05
• [Presentation] Skeletal muscle development in zebrafish (2010)
  • Author(s): 越智陽城
  • Organizer: 第5回関西小魚セミナー
  • Place of Presentation: 京都大学農学部
  • Year and Date: 2010-07-30
• [Presentation] Evolution of cis-regulatory mechanisms in paralog formation (2010)
  • Author(s): Ogino H. and Ochi H.
  • Organizer: 第43回日本発生生物学学会
  • Place of Presentation: 京都
  • Year and Date: 2010-06-21
• [Presentation] A fail-safe regulatory system generated by genome duplications for kidney development (2010)
  • Author(s): Ochi H, and Ogino H.
  • Organizer: 第43回日本発生生物学学会
  • Place of Presentation: 京都
  • Year and Date: 2010-06-21
• [Presentation] Functional analysis of epigenetic regulators, Ezh2 and Jmjd3, in Xenopus embryonic development (2010)
  • Author(s): Kawaguchi A., Ochi H., Okano M. and Ogino H.
  • Organizer: 第43回日本発生生物学学会
  • Place of Presentation: 京都
  • Year and Date: 2010-06-21
• [Presentation] Evolution of cis-regulatory mechanisms in paralog formation (2010)
  • Author(s): 荻野肇
  • Organizer: 日本発生生物学会第43回年会
  • Place of Presentation: 京都国際会議場(京都市)
  • Year and Date: 2010-06-21
• [Presentation] A fail-safe regulatory system generated by genome duplications for kidney development (2010)
  • Author(s): 越智陽城
  • Organizer: 日本発生生物学会第43回年会
  • Place of Presentation: 京都国際会議場(京都市)
  • Year and Date: 2010-06-21
• [Presentation] Developmental switch from Rohon-Beard cells to dorsal root ganglia in Xenopus (2010)
  • Author(s): 矢嶋浩
  • Organizer: 日本発生生物学会第43回年会
  • Place of Presentation: 京都国際会議場(京都市)
  • Year and Date: 2010-06-21
• [Presentation] Developmental switch from Rohon-Beard cells to dorsal root ganglia (2010)
  • Author(s): Yajima H., Suzuki M., Ochi H., Ikeda K., Sato S., Ogino H., Ueno N. and Kawakami K.
  • Organizer: 第43回日本発生生物学学会
  • Place of Presentation: 京都
  • Year and Date: 2010-06-20
• [Presentation] Functional analysis of epigenetic regulators, Ezh2 and Jmjd3, in Xenopus embryonic development (2010)
  • Author(s): 川口茜
  • Organizer: 日本発生生物学会第43回年会
  • Place of Presentation: 京都国際会議場(京都市)
  • Year and Date: 2010-06-20
• [Presentation] Different mechanisms in inhibition of limb regeneration between larval and adult Xenopus (2010)
  • Author(s): 横山仁
  • Organizer: 日本発生生物学会第43回年会
  • Place of Presentation: 京都国際会議場(京都市)
  • Year and Date: 2010-06-20
• [Presentation] Six1 acts as a molecular switch of primary sensory systems from Rohon-beard cells to DRG neurons (2010)
  • Author(s): 川上潔
  • Organizer: 11th Asian and Oceanian Conference on transcription
  • Place of Presentation: ホテル ベルパライソ(沖縄県今帰仁村)
  • Year and Date: 2010-06-04
• [Presentation] Functional analysis of the histone H3K27 methyltransferase and demethylase in Xenopus embryonic development (2010)
  • Author(s): Kawaguchi A, Ochi H., Sudou H., Okano M. and Ogino H.
  • Organizer: The 16^<th> International Conference of the international Society of differentiation
  • Place of Presentation: Nara
• [Presentation] Evolution of a fail-safe regulatory system for kidney development (2010)
  • Author(s): Ochi H., Uchiyama C., Kawaguchi A. and Ogino H.
  • Organizer: The 16^<th> International Conference of the international Society of differentiation
  • Place of Presentation: Nara
• [Presentation] 幼生期と成体期のXenopusでみられる四肢再生における異なる開始機構 (2010)
  • Author(s): 横山仁、丸岡玉枝、越智陽城、有賀章郎、大湖史、荻野肇、田村宏治
  • Organizer: 日本動物学会-東北支部大会
  • Place of Presentation: 福島
• [Presentation] Pax2/5/8パラログ遺伝子群のシス調節ネットワークの進化の解析 (2009)
  • Author(s): Ogino H. and Ochi H.
  • Organizer: 第3回日本ツメガエル研究集会、日本ツメガエル研究集会
  • Place of Presentation: 広島
  • Year and Date: 2009-10-06
• [Presentation] Wntシグナルは四肢再生に対して幼生期と成体期で異なる関与をする (2009)
  • Author(s): Yokoyama H., Ochi H., Ogino H. and Tamura K.
  • Organizer: 第80回日本動物学会
  • Place of Presentation: 静岡
  • Year and Date: 2009-09-19
• [Presentation] カエルの高効率トランスジェニックシステムを用いた機能ゲノム学的研究の展開 (2009)
  • Author(s): Ogino H. and Ochi H.
  • Organizer: 第80回日本動物学会
  • Place of Presentation: 静岡
  • Year and Date: 2009-09-19
• [Presentation] Pax2/5/8パラログ遺伝子群のシス調節ネットワークの進化の解析 (2009)
  • Author(s): Ochi H. and Ogino H.
  • Organizer: 第80回日本動物学会大会
  • Place of Presentation: 静岡
  • Year and Date: 2009-09-17
• [Presentation] アフリカツメガエル四肢発生-再生過程におけるレチノイン酸のはたらき (2009)
  • Author(s): 大湖史朗、横山仁、越智陽城、荻野肇、田村宏治
  • Organizer: 日本動物学会-東北支部大会
  • Place of Presentation: 宮城
  • Year and Date: 2009-08-01
• [Presentation] Cis-regulatory mechanisms controlling Six1 expression in the preplacodal region and sensory placode (2009)
  • Author(s): Sato S., Ikeda K., Hayshibara Y., Nakao K., Aizawa S, Ochi H., Ogino H., Kawakami K.
  • Organizer: 第42回日本発生生物学会
  • Place of Presentation: 新潟
  • Year and Date: 2009-05-29
• [Presentation] Transgenic analysis of a cis-regulatory network for the Pax3/5/8 paralog group in Xenopus ; an evolutionary view (2009)
  • Author(s): Ochi H. and Ogino H.
  • Organizer: 第42回日本発生生物学会
  • Place of Presentation: 新潟
  • Year and Date: 2009-05-29
• [Presentation] Different involvement of WNt/B-catenin signaling in limb regulation of larval and adult Xenopus (2009)
  • Author(s): Yokoyama H., Ochi H., Ogino Hajime and Tamura K.
  • Organizer: 第42回日本発生生物学会
  • Place of Presentation: 新潟
  • Year and Date: 2009-05-29
• [Presentation] Expression and functional analysis of epigenetic regulators, Eed, Ezh2, Jmjd3 and UTx in Xenopus embryonic development (2009)
  • Author(s): Okano M., kawaguchi A. Ochi H. and Ogino H.
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] Heterochronic shit in Hox-mediated activation of Sonic hedgehog leads to morphological changes during vertebrate fin evolution (2009)
  • Author(s): Sakamoto K., Onimura K., Munakata K., Suda N., Tamura, M. Ochi H. and Tanaka M.
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] Expression and functional analysis of epigenetic regulators, Eed, Ezh2, Jmjd3 and UTx in Xenopus embryonic development (2009)
  • Author(s): Okano makoto, Akane kawaguchi, Haruki Ochi, Hajime Ogino
  • Organizer: 日本分子生物学会
  • Place of Presentation: 横浜
• [Presentation] Heterochronic shit in Hox-mediated activation of Sonic hedgehog leads to morphological changes during vertebrate fin evolution (2009)
  • Author(s): Koji Sakamoto, Kho Onimura, Keijiro Munakata, Natuno Suda, Mike Tamura, Haruki Ochi, Mikiko Tanaka
  • Organizer: 日本分子生物学会
  • Place of Presentation: 横浜
• [Presentation] Pax2/5/8パラログ遺伝子群のシス調節ネットワークの進化の解析 (2009)
  • Author(s): Ogino Hagime, Haruki Ochi
  • Organizer: 第3回 日本ツメガエル研究集会
  • Place of Presentation: 広島
• [Presentation] アフリカツメガエル四肢発生・再生過程におけるレチノイン酸のはたらき (2009)
  • Author(s): 大湖史朗、横山仁、越智陽城、荻野肇、田村宏治
  • Organizer: 日本動物学会東北支部大会
  • Place of Presentation: 宮城
• [Presentation] Pax2/5/8パラログ遺伝子群のシス調節ネットワークの進化の解析 (2009)
  • Author(s): Haruki Ochi, Ogino Hagime
  • Organizer: 日本動物学会
  • Place of Presentation: 静岡
• [Presentation] Wntシグナルは四肢再生に対して幼生期と成体期で異なる関与をする (2009)
  • Author(s): Hokoyama Hitoshi, Ochi Haruki, Ogino Hajime, Tamura Koji
  • Organizer: 日本動物学会
  • Place of Presentation: 静岡
• [Presentation] カエルの高効率トランスジェニックシステムを用いた機能ゲノム学的研究の展開 (2009)
  • Author(s): Ogino Hagime, Haruki Ochi
  • Organizer: 日本動物学会
  • Place of Presentation: 静岡
• [Presentation] Cis-regulatory mechanisms controlling Six1 expression in the preplacodal region and sensory placodes (2009)
  • Author(s): Shigeru Sato, Keiko Ikeda, Yasyoori Hayshihara, Kazuki Nakao, Shin-ichi Aizawa, Haruki Ochi, Hajime Ogino, Kiyoshi Kawakami
  • Organizer: 日本発生生物学会
  • Place of Presentation: 新潟
• [Presentation] Transgenic analysis of a cis-regulatory network for the Pax3/5/8 paralog group in Xenopus ; an evolutionary view (2009)
  • Author(s): Haruki Ochi, Ogino Hagime
  • Organizer: 日本発生生物学会
  • Place of Presentation: 新潟
• [Presentation] Different involvement of WNt/B-catenin signaling in limb regulation of larval and adult Xenopus (2009)
  • Author(s): Hokoyama Hitoshi, Ochi Haruki, Ogino Hajime, Tamura Koji
  • Organizer: 日本発生生物学会
  • Place of Presentation: 新潟
• [Remarks]
  • URL: http://bsgcoe.naist.jp/ogino/