BMP-switching regulates lineage specification and migration of neural crest cells

• Project/Area Number: 21770235
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Developmental biology
• Research Institution: Nara Institute of Science and Technology
• Principal Investigator: SAITO Daisuke Nara Institute of Science and Technology, バイオサイエンス研究科, 助教 (90403360)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 神経堤細胞 / 交感神経 / 副腎 / ケモカイン / 誘引 / 細胞移動 / 反発 / 細胞選別 / 神経冠細胞

Research Abstract

Among the neural crest cell (NCC) subtypes, I focus on the sympatho-adrenal progenitor cells (SA cells), the common progenitors giving rise to sympathetic neurons (S-cells) and adrenal medulla cells (A-cells). We found that the mechanism underling SA cells migration toward dorsal aorta (DA), and BMP, SDF and Neuregulin is involved in this process.

Research Products

• [Journal Article] Genomically integrated transgenes are stably and conditionally expressed in neural crest cell-specific lineages (2011)
  • Author(s): 横田泰宏、齋藤大介、田所竜介(他1名、2番目)
  • Journal Title: Developmental Biology誌 353巻 Pages: 382-395
  • Peer Reviewed
• [Journal Article] In vivo gene manipulations of epithelial cell sheets: a novel model to study epithelial-to-mesenchymal transition (2011)
  • Author(s): 吉野剛史、齋藤大介、田所竜介(他1名、2番目)
  • Journal Title: Development,Growth and Differentiation誌 53巻 Pages: 378-388
  • NAID: 10028202714
  • Peer Reviewed
• [Journal Article] In vivo gene manipulations of epithelial cell sheets : a novel model to study epithelial-to-mesenchymal transition. (2011)
  • Author(s): Yoshino, T., et al.
  • Journal Title: Development Growth and Differentiation Volume: (in press)
  • Peer Reviewed
• [Journal Article] Genomically integrated transgenes are stably and conditionally expressed in neural crest cell-specific lineages. (2011)
  • Author(s): Yokota, Y., et al.
  • Journal Title: Developmental Biology Volume: (in press)
  • Peer Reviewed
• [Journal Article] Ephrin B2 coordinates the formation of a morphological boundary and cell epithelialization during somite segmentation (2009)
  • Author(s): 渡邊忠良、佐藤有紀、齋藤大介(他2名、3番目)
  • Journal Title: Proc.Natl.Acad.Sci.USA誌 106巻 Pages: 7467-7472
  • Peer Reviewed
• [Journal Article] Notch signal is sufficient to direct an endothelial conversion from non-endothelial somitic cells conveyed to the aortic region by CXCR4 (2009)
  • Author(s): 大畑絵美、田所竜介、佐藤有紀、齋藤大介(他1名、4番目)
  • Journal Title: Developmental Biology誌 335巻 Pages: 33-42
  • Peer Reviewed
• [Journal Article] Ephrin B2 coordinates the formation of a morphological boundary and cell epithelialization during somite segmentation. (2009)
  • Author(s): Watanabe, T.
  • Journal Title: Proc.Natl.Acad.Sci.USA 106(18) Pages: 7467-7472
  • Peer Reviewed
• [Journal Article] Notch signal is sufficient to direct an endothelial conversion from non-endothelial somitic cells conveyed to the aortic region by CXCR4. (2009)
  • Author(s): Ohata, E.
  • Journal Title: Developmental Biology 335 Pages: 33-42
  • Peer Reviewed
• [Presentation] BMP-switching regulates lineage specification and migration of neural crest cells (2010)
  • Author(s): 齋藤大介、大畑絵美、村井英隆、高瀬悠太、高橋淑子
  • Organizer: The 16th International Conference of the International Society of Differentiation
  • Place of Presentation: 奈良
  • Year and Date: 2010-11-15
• [Presentation] BMP-switching regulates lineage specification and migration of neural crest cells. (2010)
  • Author(s): Saito, D.
  • Organizer: The 16^<th> International Conference of the International Society of Differentiation
  • Place of Presentation: 奈良県新公会堂
  • Year and Date: 2010-11-15
• [Presentation] BMP-switching regulates lineage specification and migration of neural crest cells (2010)
  • Author(s): 齋藤大介、大畑絵美、村井英隆、高瀬悠太、高橋淑子
  • Organizer: Society for Developmental Biology 69th Annual Meeting
  • Place of Presentation: アメリカ・ニューメキシコ州・アルバカーキ
  • Year and Date: 2010-08-07
• [Presentation] BMP-switching regulates lineage specification and migration of neural crest cells. (2010)
  • Author(s): Saito, D.
  • Organizer: Society for Developmental Biology 69^<th> Annual Meeting
  • Place of Presentation: アメリカ・ニューメキシコ・アルバカーキ
  • Year and Date: 2010-08-07
• [Presentation] BMP-switching regulates lineage specification and migration of neural crest cells (2010)
  • Author(s): 齋藤大介、大畑絵美、村井英隆、高瀬悠太、高橋淑子
  • Organizer: 第43回日本発生生物学会年会
  • Place of Presentation: 京都
  • Year and Date: 2010-06-21
• [Presentation] BMP-switching regulates lineage specification and migration of neural crest cells. (2010)
  • Author(s): Saito, D.
  • Organizer: 第43回日本発生生物学会年会
  • Place of Presentation: 京都国際会館
  • Year and Date: 2010-06-21
• [Presentation] BMP switching regulates migration and subtype segregation of neural crest cells (2010)
  • Author(s): 齋藤大介、大畑絵美、村井英隆、高瀬悠太、高橋淑子
  • Organizer: CDB Symposium 2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-03-24
• [Presentation] BMP switching regulates migration and subtype segregation of neural crest cells (2010)
  • Author(s): Daisuke Saito
  • Organizer: CDB Symposium 2010
  • Place of Presentation: Kobe, Japan
• [Book] 最新医学(発生と幹細胞:神経冠細胞の移動機構)(最新医学社「幹細胞研究の最近の進歩(後編)-組織幹細胞-) (2009)
  • Author(s): 齋藤大介、田所竜介、高橋淑子
• [Book] 最新医学「幹細胞研究の最近の進歩(後編)-組織幹細胞-」(発生と幹細胞:神経冠細胞の移動機構) (2009)
  • Author(s): 齋藤大介
• [Remarks] ホームページアドレス
  • URL: http://bsw3.naist.jp/takahashi/takahashi.html