Analysis of regulatory mechanisms for Xenopus embryogenesis dependent on the dynamic shape changes of cytoplasmic organelles
| Project/Area Number |
21770236
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
UENO Shuichi 山口大学, 大学院・医学系研究科, 助教 (80363092)
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| Research Collaborator |
IWAO Yasuhiro 山口大学, 大学院・医学系研究科, 教授 (10144916)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 細胞内小器官 / 細胞周期 / Xenopus / Convergent Extension / P-body / PI3K / PTEN / MBT |
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| Research Abstract |
We have found that the cytoplasmic organelles changed dynamically their shape during which the morphogenesis began after cell proliferation at MBT. For example at MBT, the golgi apparatus, which is necessary for protein traffic and modification, was reassembled from its fragments, and the P-body, in which mRNAs degrade efficiently, emerged. We think that these changes were necessary for protein secretion and maternal mRNA degradation after MBT. Otherwise, we showed that the molecular mechanism which triggered the initiation of cell cycle elongation at MBT.
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Report
(4 results)
Research Products
(17 results)
