| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
Embryonic appendicular structures, including the developing external genitalia, are suitable models to analyze the developmental mechanisms of organ protrusion and outgrowth. Although several studies have evaluated individual functions of different growth factors on appendicular growth, the coordinated function of signaling cascades is poorly understood. Our results provide new insights into the integration of growth factor signaling (i.e. hedgehog, Wnt and Fgfs) in the appendicular developmental programs regulating external genitalia development. We also demonstrated the interaction of such growth factors and sex steroid hormones (androgens) during later stage of external genital development.
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