Quantitative Analysis of Morphogenesis by Whole-animal 4D-imaging
| Project/Area Number |
21770241
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | Keio University |
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Principal Investigator |
HOTTA Kohji 慶應義塾大学, 理工学部, 講師 (80407147)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 末梢神経 / 3Dライブイメージング / 進化 / 3D / ホヤ / 神経管閉鎖 / 脊索動物 / 尾芽胚 / 器官形成 / 脊索 / 形態形成 / ASNET / イメージング |
|---|
| Research Abstract |
To understand morphogenesis at single-cell-level in chordate organogenesis period, ascidian embryo was used in this study. By 3D imaging of ascidian larva, a novel peripheral neuron network structure was found at larval outer tunic. Computer model of the tailbud embryo were made. By 3D-live(4D) imaging of neural tube closure, it was suggested that two independent cell movements accomplish the closure. Thus high-resolution imaging of ascidian embryogenesis enables us to understand how each cell cause morphogenesis of tissue, organ and whole-animal level.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] The ANISEED database : digital representation, formalisation and elucidation of a chordate developmental program2010
Author(s)
O.Tassy, D.Dauga, F.Daian, D.Sobral, F.Robin, P.Khoueiry, D.Salgado, V.Fox, D.Caillo, M.Contensin, Renaud Schiappa, Anne Rios, Guillaume Luxardi, M.Gilchrist, K.Makabe, K.Hotta, Fujiwara, T.Kusakabe, N.Satoh, Y.Satou, P.Lemaire
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Journal Title
Genome Research.
Volume: 20
Pages: 1459-68
Related Report
Peer Reviewed
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[Presentation] ASNET : Actin-based network structure in the tunic of ascidian larva2010
Author(s)
Kohji HOTTA, Hiroshi Q TERAKUBO, Mitsuru Nakamura, Yoko NAKAJIMA, Yasunori SASAKURA, Takeo HORIE, Alu KONNO, Hiroki TAKAHASHI, Kazuo INABA, Kotaro OKA
Organizer
Society for Developmental Biology 69th Annual Meeting-Jointly with Japanese Society of Developmental Biologists
Place of Presentation
New Mexico, USA
Year and Date
2010-08-08
Related Report
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[Presentation] ASNET : Actin-based network structure in the tunic of ascidian larva2010
Author(s)
Kohji HOTTA, Hiroshi Q TERAKUBO, Mitsuru Nakamura, Yoko NAKAJIMA, Yasunori SASAKURA, Takeo HORIE, Alu KONNO, Hiroki TAKAHASHI, Kazuo INABA, Kotaro OKA
Organizer
Society for Developmental Biology 69th Annual Meeting -Jointly with Japanese Society of Developmental Biologists
Place of Presentation
Albuquerque, New Mexico, USA
Year and Date
2010-08-08
Related Report
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[Presentation] Actin-based network structure in the tunic of ascidian larva revealed by confocal laser scanning andtransmission electron microscopes2010
Author(s)
KOHJI HOTTA, Hiroshi Terakubo, Yoko Nakajima, Yasunori Sasakura, Takeo Horie, Alu Konno, Hiroki, Takahashi, Kazuo Inaba, Kotaro Oka
Organizer
43rd Annual Meeting for the Japanese Society of Developmental Biologists Jointly Sponsored by the Asia-Pacific Developmental Biology Network
Place of Presentation
Kyoto, International Conference Center
Year and Date
2010-06-21
Related Report
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[Presentation] Ascidian dendritic network in tunic2010
Author(s)
Kohji HOTTA, Hiroshi Q TERAKUBO, Yoko NAKAJIMA, Alu KONNO, Takeo HORIE, Hiroki TAKAHASHI, Yasunori SASAKURA, Kazuo INABA, Kotaro OKA
Organizer
2ND JOINT MEETING OF THE SFBD AND JSDB 2010-From Cells to Organs
Place of Presentation
Institut Pasteur, Paris, France
Year and Date
2010-05-27
Related Report
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[Presentation] Ascidian dendritic network in tunic2010
Author(s)
Kohji HOTTA, Hiroshi Q TERAKUBO, Yoko NAKAJIMA, Alu KONNO, Takeo HORIE, Hiroki TAKAHASHI, Yasunori SASAKURA, Kazuo INABA, Kotaro OKA
Organizer
2ND JOINT MEETING OF THE SFBD AND JSDB 2010
Place of Presentation
Institut Pasteur, Paris, France
Year and Date
2010-05-27
Related Report
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