| Project/Area Number |
21770247
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
SHIBATA Yukimasa The Institute of Physical and Chemical Research, 細胞運命研究チーム, 研究員 (80314053)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | クロマチン / アセチル化ヒストン / 運命の維持 / C. elegans / C.elegans / BET-1 / ヒストンアセチル化 / H2A.z |
|---|
| Research Abstract |
The requirement of histone acetylation in the maintenance of cell fates had not been clear. However, recently, I showed that C. elegans acetylate histone binding protein, BET-1, is required for the maintenance of cell fates. In this research project, I found that BET-1 functions through developmental determinants. In addition, their expressions appear to be regulated by histone variant, H2A.z, and histone demethylase, UTX-1.
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