Functional analysis of BMP binding protein, Cv2, in nephorogenesis
| Project/Area Number |
21770249
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | Kyoto University |
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Principal Investigator |
IKEYA Makoto Kyoto University, 再生医科学研究所, 研究員 (20442923)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | 遺伝学 / 発生・分化 / 細胞・組織 / シグナル伝達 / 循環器・高血圧 |
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| Research Abstract |
The fine-tuning of BMP signals is critical for many aspects of complex organogenesis. We show that the augmentation of BMP signaling by a BMP-binding secreted factor, Crossveinless2 (Cv2), is essential for the early embryonic development of mammalian nephrons and also that Cv2 exerts its pro-BMP nephrogenic function Tsg- dependently. We published these findings in the journal "Develpmental Biology".
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Report
(3 results)
Research Products
(8 results)
