Functional analysis of BMP binding protein, Cv2, in nephorogenesis

• Project/Area Number: 21770249
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Developmental biology
• Research Institution: Kyoto University
• Principal Investigator: IKEYA Makoto Kyoto University, 再生医科学研究所, 研究員 (20442923)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
• Keywords: 遺伝学 / 発生・分化 / 細胞・組織 / シグナル伝達 / 循環器・高血圧

Research Abstract

The fine-tuning of BMP signals is critical for many aspects of complex organogenesis. We show that the augmentation of BMP signaling by a BMP-binding secreted factor, Crossveinless2 (Cv2), is essential for the early embryonic development of mammalian nephrons and also that Cv2 exerts its pro-BMP nephrogenic function Tsg- dependently. We published these findings in the journal "Develpmental Biology".

Research Products

• [Journal Article] Cv2, functioning as a pro-BMP factor via twisted gastrulation, is required for early development of nephron precursors. (2010)
  • Author(s): Ikeya M, et al.
  • Journal Title: Developmental Biology Vol 337 Pages: 405-414
  • Peer Reviewed
• [Journal Article] Cv2, functioning as a pro-BMP factor via twisted gastrulation, is required for early development of nephron precursors (2010)
  • Author(s): Ikeya M, et al.
  • Journal Title: Developmental Biology Volume: 337 Pages: 405-414
  • Peer Reviewed
• [Presentation] Tsg依存的BMP促進因子Cv2は、ネフロン前駆体の凝集を制御する (2009)
  • Author(s): 池谷真, 他
  • Organizer: 第42回日本発生生物学会大会
  • Place of Presentation: 新潟
  • Year and Date: 2009-05-30
• [Presentation] Tsg依存的BMP促進因子Cv2は、ネフロン前駆体の凝集を制御する (2009)
  • Author(s): 池谷真, 他
  • Organizer: 第42回日本発生生物学会大会
  • Place of Presentation: 朱鷺メッセ 新潟コンベンションセンター(新潟県)
  • Year and Date: 2009-05-30
• [Presentation] Cv2 is required for early nephron development as a pro-BMP factor functioning via Twisted gastrulation (2009)
  • Author(s): 池谷真, 他
  • Organizer: 日本分子生物学会第9回春期シンポジウム
  • Place of Presentation: 宮崎
  • Year and Date: 2009-05-11
• [Presentation] Gv2 is required for early nephron development as a pro-BMP factor functioning via Twisted gastrulation (2009)
  • Author(s): 池谷真, 他
  • Organizer: 日本分子生物学会第9回春季シンポジウム
  • Place of Presentation: シーガイア ワールドコンベンションセンター・サミット(宮崎県)
  • Year and Date: 2009-05-11
• [Book] Gatewayを用いた遺伝子導入マニュアル(第6章) (2009)
  • Author(s): 池谷真, 他
  • Publisher: シュプリンガー・ジャパン株式会社
• [Book] Gatewayを用いた遺伝子導入マニュアル 第6章(p75-86) (2009)
  • Author(s): 池谷真, 他
  • Total Pages: 12
  • Publisher: シュプリンガー・ジャパン株式会社