Mechanisms of the PCP signal transduction to bend neuroepithelial layer
| Project/Area Number |
21770250
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | Kobe University (2011-2012)
The Institute of Physical and Chemical Research (2009-2010) |
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Principal Investigator |
NISHIMURA Tamako 神戸大学, 自然科学系先端融合研究環・重点研究部 (40415261)
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| Project Period (FY) |
2009 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥5,284,136 (Direct Cost: ¥4,064,720、Indirect Cost: ¥1,219,416)
Fiscal Year 2012: ¥1,254,136 (Direct Cost: ¥964,720、Indirect Cost: ¥289,416)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 神経管 / 平面内極性 / F-アクチン / ミオシン / neural tube / planar cell polarity / アクトミオシン / 神経上皮細胞 |
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| Research Abstract |
Neural tube is the precursor of the central nervous system, andformed by the bending of the neural plate along the body axis, although underlying mechanisms were not completely understood. We found that at the apical cell-cell contact sites of the neuroepithelial cells, which constitute neural plate, actomyosin cytoskeleton is activated and contracted in the direction perpendicular to the body axis, leading to a tube formation. Furthermore, we uncovered a novel signaling pathway in which the planar cell polarity signaling regulates the polarized activation of actomyosin in the bending neural plate.
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Report
(5 results)
Research Products
(9 results)
