Molecular developmental study of the mammalian middle ear evolution

• Project/Area Number: 21770259
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Evolutionary biology
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: TAKECHI Masaki The Institute of Physical and Chemical Research, 形態進化研究グループ, 研究員 (10455355)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 中耳 / 中耳腔 / 耳小骨 / 咽頭弓 / 顎骨弓 / 一次顎関節 / 形態進化 / Evo-Devo / 鼓膜 / 進化発生 / 神経堤細胞 / 舌顎弓

Research Abstract

We reviewed previous comparative morphological and molecular developmental studies regarding the evolution of the mammalian middle ear and proposed that the most important issue in the evolution is "How did the tympanic membrane form in the lower jaw domain in the mammalian ancestor?" (Takechi and Kuratani, 2010). We next examined chicken and mouse embryos to identify mammal-specific developmental events which led the tympanic membrane in the lower jaw domain. Our data suggested that a dorsal shift of the primary jaw joint (articulation in the quadrate and articular) with respect to the first pharyngeal pouch in the mammalian ancestor led the tympanic membrane in the lower jaw domain.

Research Products

• [Journal Article] 哺乳類における顎と中耳の発生と進化 (2010)
  • Author(s): 武智正樹、倉谷滋
  • Journal Title: エナメル質比較発生学懇話会記録 11 Pages: 26-44
• [Journal Article] History of studies on mammalian middle ear evolution : A comparative morphological and developmental biology perspective. (2010)
  • Author(s): Takechi, M., Kuratani,S
  • Journal Title: Journal of Experimental Zoology (Mol. Dev. Evol.) 314 Pages: 26-44
  • Peer Reviewed
• [Journal Article] History of studies on mammalian middle ear evolution: A comparative morphological and developmental biology perspective. (2010)
  • Author(s): Takechi, M., Kuratani, S.
  • Journal Title: Journal of Experimental Zoology (Mol.Dev.Evol.) Volume: 314 Pages: 417-433
  • Peer Reviewed
• [Journal Article] 哺乳類における顎と中耳の発生と進化 (2010)
  • Author(s): 武智正樹、倉谷滋
  • Journal Title: エナメル質比較発生学懇話会記録 Volume: 11 Pages: 26-44
• [Presentation] Comparative Embryological Study of the Mammalian Middle Ear Evolution. (2011)
  • Author(s): Takechi, M., Hirai, T., Adachi, N., Hirasawa, T., Kuratani, S
  • Organizer: 第116回日本解剖学会総会・全国学術集会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-03-28
• [Presentation] Comparative Embryological Study of the Mammalian Middle Ear Evolution (2011)
  • Author(s): Takechi, M., Hirai, T., Adachi, N., Hirasawa, T., Kuratani, S.
  • Organizer: 第116回日本解剖学会総会・全国学術集会
  • Place of Presentation: 横浜市
  • Year and Date: 2011-03-28
• [Presentation] Molecular Developmental Study of the Mammalian Middle Ear Evolution. (2011)
  • Author(s): Takechi, M., Hirai, T., Adachi,N., Hirasawa, T., Kuratani, S
  • Organizer: The 20th CDB meeting : Molecular Bases for Evolution of Complex Traits
  • Place of Presentation: Kobe, Japan.
  • Year and Date: 2011-02-23
• [Presentation] Molecular Developmental Study of the Mammalian Middle Ear Evolution. (2011)
  • Author(s): Takechi, M., Hirai, T., Adachi, N., Hirasawa, T., Kuratani, S.
  • Organizer: The 20th CDB meeting: Molecular Bases for Evolution of Complex Traits
  • Place of Presentation: 神戸市
  • Year and Date: 2011-02-23
• [Presentation] 発生学者、古生物学に出会う (2010)
  • Author(s): 武智正樹
  • Organizer: 第3回Evo-Devo青年の会「器官形成の進化的理解に向けて」
  • Place of Presentation: 東京慈恵医大学
  • Year and Date: 2010-11-27
• [Presentation] 脊椎動物のかたちづくりの発生と進化~聴覚器官の形態進化を例に~新潟大学医研究科 (2010)
  • Author(s): 武智正樹
  • Organizer: 第2回肉眼解剖学・形態形成学セミナー
  • Place of Presentation: 新潟大学
  • Year and Date: 2010-08-20
• [Presentation] Comparative Embryological Study for Understanding of the Mammalian Middle Ear Evolution. (2010)
  • Author(s): Takechi, M., Hirai,T., Kuratani, S
  • Organizer: 9th International Congress of Vertebrate Morphology
  • Place of Presentation: Punta del Este, Uruguay.
  • Year and Date: 2010-07-28
• [Presentation] Comparative Embryological Study for Understanding of the Mammalian Middle Ear Evolution. (2010)
  • Author(s): Takechi, M., Hirai, T., Kuratani, S.
  • Organizer: 9th International Congress of Vertebrate Morphology
  • Place of Presentation: Punta del Este, Uruguay
  • Year and Date: 2010-07-28
• [Presentation] Comparative Developmental Study for Understanding of the Mammalian Middle Ear Evolution. (2010)
  • Author(s): Takechi, M., Hirai,T., Kuratani, S
  • Organizer: 3rd meeting of the European society for evolutionary developmental biology
  • Place of Presentation: Paris, France.
  • Year and Date: 2010-07-07
• [Presentation] Comparative Developmental Study for Understanding of the Mammalian Middle Ear Evolution. (2010)
  • Author(s): Takechi, M., Hirai, T., Kuratani, S.
  • Organizer: 3rd meeting of the European society for evolutionary developmental biology
  • Place of Presentation: Paris, France
  • Year and Date: 2010-07-07
• [Presentation] 脊椎動物頭部と顎の進化と発生 (2010)
  • Author(s): 武智正樹
  • Organizer: 九州大学歯学部小児歯科学
  • Place of Presentation: 九州大学馬出地区キャンパス
  • Year and Date: 2010-04-08
• [Presentation] 哺乳類の中耳はどのようにして顎関節から進化したのか? (2010)
  • Author(s): 武智正樹、平井珠美、倉谷滋
  • Organizer: 第115回日本解剖学会総会・全国学術集会
  • Place of Presentation: 岩手県民会館
  • Year and Date: 2010-03-29
• [Presentation] 脊椎動物における顎の進化 (2010)
  • Author(s): 武智正樹
  • Organizer: 第115回日本解剖学会総会・全国学術集会シンポジウム
  • Place of Presentation: 岩手県民会館
  • Year and Date: 2010-03-29
• [Presentation] 脊椎動物における顎の進化 (2010)
  • Author(s): 武智正樹
  • Organizer: 第115回日本解剖学会総会・全国学術集会
  • Place of Presentation: 岩手市・岩手県民会館
  • Year and Date: 2010-03-29
• [Presentation] 哺乳類の中耳はどのようにして顎関節から進化したのか? How did the mammalian middle ear evolve from the jaw joint? (2010)
  • Author(s): 武智正樹、平井珠美、倉谷滋
  • Organizer: 第115回日本解剖学会総会・全国学術集会
  • Place of Presentation: 岩手市・岩手県民会館
  • Year and Date: 2010-03-29
• [Presentation] 我々の耳小骨はどのようにして3つになったのか? (2010)
  • Author(s): 武智正樹
  • Organizer: 第328回医学研究の基礎を語り合う集い
  • Place of Presentation: 東京慈恵会医科大学
  • Year and Date: 2010-03-26
• [Presentation] Molecular Developmental Study for Understanding of the Mammalian Middle Ear Evolution (2010)
  • Author(s): 武智正樹、平井珠美、倉谷滋
  • Organizer: CDB symposium, Frontiers in organogenesis
  • Place of Presentation: 理化学研究所発生・再生科学総合研究センター
  • Year and Date: 2010-03-25
• [Presentation] Molecular Developmental Study for Understanding of the Mammalian Middle Ear Evolution. (2010)
  • Author(s): Takechi, M., Hirai,T., Kuratani, S
  • Organizer: CDB Symposium, Frontiers in Organogenesis
  • Place of Presentation: Kobe, Japan.
  • Year and Date: 2010-03-24
• [Presentation] 脊椎動物の「かたち」を比較する~哺乳類中耳の形態進化を例に~ (2010)
  • Author(s): 武智正樹
  • Organizer: 第3回甲南大学生物学科シンポジウム
  • Place of Presentation: 甲南大学
  • Year and Date: 2010-01-13
• [Presentation] 脊椎動物の顎の進化 (2009)
  • Author(s): 武智正樹
  • Organizer: 日本大学松戸歯学部大学院セミナー
  • Place of Presentation: 日本大学
  • Year and Date: 2009-12-28
• [Presentation] 哺乳類中耳の形態進化 (2009)
  • Author(s): 武智正樹
  • Organizer: 日本動物学会第80回大会関連集会第1回Evo-Devo青年の会
  • Place of Presentation: グランシップ静岡
  • Year and Date: 2009-09-17
• [Presentation] 哺乳類の中耳はどのようにして顎関節から進化したのか? (2009)
  • Author(s): 武智正樹、平井珠美、倉谷滋
  • Organizer: 日本動物学会第80回大会
  • Place of Presentation: グランシップ静岡
  • Year and Date: 2009-09-17
• [Presentation] 哺乳類の中耳はどのようにして顎関節から進化したのか? (2009)
  • Author(s): 武智正樹、平井珠美、倉谷滋
  • Organizer: 第80回日本動物学会
  • Place of Presentation: 静岡市・グランシップ
  • Year and Date: 2009-09-17
• [Presentation] How did mammals evolve the middle ear from the jaw joint? : From the standpoint of Evo-Devo (2009)
  • Author(s): 武智正樹、平井珠美、倉谷滋
  • Organizer: 第42回日本発生生物学会
  • Place of Presentation: 新潟市・朱鷺メッセ
  • Year and Date: 2009-05-30
• [Presentation] How did mammals evolve the middle ear from the jaw joint? : From the standpoint of Evo-Devo (2009)
  • Author(s): Takechi, M., Hirai,T., Kuratani, S
  • Organizer: 日本発生生物学会第42回大会
  • Place of Presentation: 新潟朱鷺メッセ
  • Year and Date: 2009-05-29
• [Presentation] Evolution and development of the mammalian middle ear. (2009)
  • Author(s): Takechi, M., Kuratani, S
  • Organizer: The 18th CDB meeting: Common themes and new concepts in sensory formation
  • Place of Presentation: Kobe, Japan.
  • Year and Date: 2009-04-13
• [Remarks] ホームページ等
  • URL: http://www.cdb.riken.jp/emo/index.html