Function of selenium-delivering proteins and regulation of selenium trafficking
| Project/Area Number |
21780094
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied biochemistry
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
MIHARA Hisaaki Ritsumeikan University, 生命科学部, 准教授 (30324693)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | セレン / 微量元素 / タンパク質 / セレノシステイン / セレンタンパク質 / 翻訳 |
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| Research Abstract |
In this study, proteins and enzymes involved in selenium metabolism and selenoprotein biosynthesis are investigated by crystal structural analysis of proteins in the form of a complex with a reaction intermediate, kinetic analysis, and ESI-MS analysis. Structure-function relationships of selenium-specific chemical reactions by the proteins and enzymes were revealed, establishing a molecular basis for the function of selenium as a trace element.
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Report
(3 results)
Research Products
(51 results)
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[Presentation] 亜セレン酸還元経路の探索2010
Author(s)
今井岳志, 三原久明, 栗原達夫, 江崎信芳
Organizer
BMB2010
Place of Presentation
神戸ポートアイランド(兵庫県)
Year and Date
2010-12-10
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[Presentation] Physiological function and regulation of mammalian selenocysteine lyase.2010
Author(s)
Kurokawa S, Winfrey V, Takehashi M, Tanaka H, Mihara H, Kurihara T, Tanaka S, Olson G, Hill K, Burk R.
Organizer
9th International Symposium on Selenium in Biology and Medicine (Selenium 2010).
Place of Presentation
Kyoto University (Kyoto, Japan)
Year and Date
2010-06-02
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