| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
We are focus on the roles of the Ca^<2+>/ calmodulin-dependent protein phosphatase calcineurin in budding yeast. Especially, here, we investigated a relationship between Ca^<2+>-signaling and lifespan. We found that Ca^<2+> affected the replicative lifespan(RLS) of yeast. The increase in calcineurin activity by either the zds1 deletion or the constitutively activated calcineurin reduced RLS. Further, the calcineurin deletion per se promoted ageing without impairing the gene silencing typically observed in short-lived sir mutants, indicating that calcineurin plays an important role in a regulation of RLS even under normal growth condition. Thus, our results indicate that Ca^<2+> homeostasis/ Ca^<2+>-signaling is required to regulate longevity in budding yeast.
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