Studies on the solid surface-binding mechanism of an intrinsically disordered protein and development of specific biological/inorganic interfaces
| Project/Area Number |
21780096
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied biochemistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
IKEDA Takeshi Hiroshima University, 大学院・先端物質科学研究科, 助教 (10505754)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 天然変性タンパク質 / 界面 / シリカ / シリコン |
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| Research Abstract |
The silica-binding protein "Si-tag" belongs to a family of intrinsically disordered (ID) proteins that exist as dynamic ensembles of rapidly fluctuating structures in aqueous solution. Experimental and theoretical studies have shown that the ID regions in Si-tag act in unison to bind strongly to silica surfaces. Si-tag should interact with a large area of the silica surface due to the relatively large number of residues in its extended, disordered regions. Our study suggests that flexible ID proteins have tremendous potential for connecting biomolecules to inorganic materials.
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Report
(3 results)
Research Products
(16 results)
