Studies of cGMP signaling in neurons.
| Project/Area Number |
21780098
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied biochemistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
YUASA Keizo The University of Tokushima, 大学院・ソシオテクノサイエンス研究部, 助教 (70363132)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 情報伝達 / シグナル伝達 / cGMP / プロテインキナーゼ / 神経細胞 / 神経突起形成 |
|---|
| Research Abstract |
1. Rho effector, rhotekin, was phosphorylated by cGK I. Phosphorylated rhotekin was disassociated from cGK I, and significantly suppressed lysophosphatidic acid- and rho- induced neurite retraction in Neuro2A cells.
2. cGK I interacted with and phosphorylated transient receptor potential channel subfamily C member 7 (TRPC7), contributing to the quick and accurate regulation of calcium influx and CREB phosphorylation.
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Report
(3 results)
Research Products
(16 results)
