| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Research Abstract |
1. Rho effector, rhotekin, was phosphorylated by cGK I. Phosphorylated rhotekin was disassociated from cGK I, and significantly suppressed lysophosphatidic acid- and rho- induced neurite retraction in Neuro2A cells.
2. cGK I interacted with and phosphorylated transient receptor potential channel subfamily C member 7 (TRPC7), contributing to the quick and accurate regulation of calcium influx and CREB phosphorylation.
|
