Regulation of blood pressure by secreted adipocyte-derived leucine aminopeptidase
| Project/Area Number |
21780103
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied biochemistry
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| Research Institution | Teikyo Heisei University (2010)
The Institute of Physical and Chemical Research (2009) |
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Principal Investigator |
GOTO Yoshikuni Teikyo Heisei University, 薬学部, 助教 (90455345)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | アミノペプチダーゼ / 血圧調節 / マクロファージ / 一酸化窒素 / 分泌 / インターフェロン / リポ多糖 / LPS / 貪食 |
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| Research Abstract |
Adipocyte-derived leucine amnopeptidase (A-LAP) may play role in the blood pressure regulation. In this study, it is revealed that ER-retained A-LAP is secreted from macrophages in response to activation by treatment with lipopolysaccharide and interferon-γ, and supply of arginine for nitric oxide synthesis from peptide to cells. These results suggest that secretion of A-LAP is important for hypertensive action.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzyme.2011
Author(s)
Evnouchidou I, Kamal RP, Seregin SS, Goto Y, Tsujimoto M, Hattori A, Voulgari PV, Drosos AA, Amalfitano A, York IA, Stratikos E.
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Journal Title
J Immunol. 186
Pages: 1909-1913
Related Report
Peer Reviewed
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