Biosynthesis of natural antitumor agents and their rationally engineered analogs in Escherichia coli
Project/Area Number |
21780106
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Bioproduction chemistry/Bioorganic chemistry
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Research Institution | University of Shizuoka |
Principal Investigator |
WATANABE Kenji University of Shizuoka, 薬学部, 准教授 (50360938)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | 天然物化学 / 化学生物学 / 天然物 / 生合成 / 抗生物質 / 異種発現 / ペプチド / 酵素 / 物質生産 / サフラマイシン / 遺伝子 / 酵母 / 非リボソーム依存性ペプチド |
Research Abstract |
Biosynthesis of natural antitumor agents and their rationally engineered analogs in Escherichia coli
|
Report
(3 results)
Research Products
(42 results)
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[Journal Article] Intriguing substrate tolerance of epoxide hydrolase Lsd19 involved in biosynthesis of the ionophore antibiotic lasalocid A.2010
Author(s)
Matsuura, Y., Shichijo, Y., Minami, A., Migita, A., Oguri, H., Watanabe, M., Tokiwano, T., Watanabe, K., Oikawa, H.
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Journal Title
Org.Lett. 12
Pages: 2226-2229
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[Journal Article] Sequence and analysis of the SF2575 gene cluster and characterization of key tailoring enzyme.2009
Author(s)
Pickens, L.B., Wang, P., Zhou, H., Kim, W., Watanabe, K., Gomi, S., Tang, Y.
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Journal Title
J.Am.Chem.Soc. 131
Pages: 17677-17689
Related Report
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[Journal Article] Escherichia coli allows efficient modular incorporation of newly isolated quinomycin biosynthetic enzyme into echinomycin biosynthetic pathway for rational design and synthesis of potent antibiotic unnatural natural product.2009
Author(s)
Watanabe, K., Hotta, K., Nakaya, M., Praseuth, A.P., Wang, C.C.C., Inada, D., Takahashi, K., Fukushi, F., Oguri, H., Oikawa, H.
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Journal Title
J.Am.Chem.Soc. 131
Pages: 9347-9353
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[Journal Article] Rationally Engineered Total Biosynthesis of a Synthetic Analog of a Natural Quinomycin Depsipeptide in Escherichia coli.2009
Author(s)
Watanabe, K., Hotta, K., Praseuth, A.P., Searcey, M., Wang, C.C.C., Oguri, H., Oikawa, H.
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Journal Title
ChemBioChem 10
Pages: 1965-1968
Related Report
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[Journal Article] Chromatin-level regulation of biosynthetic gene clusters.2009
Author(s)
Bok, J.W., Chiang, Y. M., Szewczyk, E., Reyes-Domingez, Y., Davidson, A.D., Sanchez, J.F., Lo, H.C., Watanabe, K., Strauss, J., Oakley, B.R., Wang, C.C.C., Keller, N.P.
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Journal Title
Nature Chemical Biology 5
Pages: 462-464
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[Journal Article] Identification of a gene cluster of polyether antibiotic lasalocid from Streptomyces lasaliensis.2009
Author(s)
Migita, A., Watanabe, M., Hirose, Y., Watanabe, K., Tokiwano, T., Kinashi, H., Oikawa, H.
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Journal Title
Biosci.Biotechnol.Biochem. 73
Pages: 169-176
NAID
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[Journal Article] Involvement of common intermediate L-3-hydroxyknyurenine in the chromophore biosynthesis of quinomycin family antibiotics.
Author(s)
Hirose, Y., Watanabe, K., Minami, A., Nakamura, T., Oguri, H., Oikawa, H.
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Journal Title
Related Report
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[Journal Article] A comprehensive overview on genomically directed assembly of aromatic polyketides and macrolide lactones using fungal megasynthases.
Author(s)
Saruwatari, T., Praseuth, A. P., Sato, M., Torikai, K., Noguchi, H., Watanabe, K.
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Journal Title
NAID
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