Search for novel families of terpene cyclases from bacteria and analyses of physiological functions and bioactivities of C35 terpenes
| Project/Area Number |
21780109
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Bioproduction chemistry/Bioorganic chemistry
|
|---|
| Research Institution | Niigata University |
|---|
Principal Investigator |
SATO Tsutomu Niigata University, 自然科学系, 准教授 (80334655)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | テルペン / テルペン環化酵素 / Mycobacterium / 枯草菌 / イソプレノイド / プレニル鎖伸長酵素 / プレニル鎖還元酵素 / 生合成 |
|---|
| Research Abstract |
A bifunctional Z-prenyltransferase that preferentially synthesize C_<35> or C_<50> products was found from the study on the mycobacterial C_<35> terpenes. The structure of two novel C_<35> terpenes suggested that a prenyl reductase reducing both E and Z prenyl residues was responsible for the biosynthesis of C_<35> terpenes. On the other hand, a novel family of terpene cyclases and tetraprenyl-β-curcumene cyclase from Bacillus subtilis could be identified by the in vitro enzymatic reaction.
|
Report
(3 results)
Research Products
(36 results)
