Characterization of intestinal barrier defect in metabolic syndrome and the ameliorative effect of food factors

• Project/Area Number: 21780117
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Food science
• Research Institution: Hiroshima University
• Principal Investigator: SUZUKI Takuya Hiroshima University, 大学院・生物圏科学研究科, 講師 (30526695)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 栄養科学 / メタボリックシンドローム / 消化管バリア機能 / タイトジャンクション

Research Abstract

Studies using animal and cell culture models were conducted to investigate the mechanism(s) underlying the intestinal barrier defects in metabolic syndrome. The barrier defect was induced in the small intestines of the diet-induced obese rats, which was associated with the decreases in the tight junction protein expression. The experiment using the cultured intestinal cells showed that the barrier defect was induced by excessive dietary lipid and subsequent bile juice secretion.

Research Products

• [Journal Article] Dietary fat and bile juice, but not obesity, are responsible for the increase in small intestinal permeability induced through the suppression of tight junction protein expression in LETO and OLETF rats (2010)
  • Author(s): Takuya Suzuki, Hiroshi Hara
  • Journal Title: Nutrition and Metabolism 12 Pages: 7-19
  • NAID: 120002063215
  • Peer Reviewed
• [Journal Article] Dietary fat and bile juice, but not obesity, are responsible for the increase in small intestinal permeability induced through the suppression of tight junction protein expression in LETO and OLETF rats (2010)
  • Author(s): Suzuki T, Hara H.
  • Journal Title: Nutrition & Metabolism Volume: 12 Pages: 7-19
  • NAID: 120002063215
  • Peer Reviewed
• [Presentation] 小腸タイトジャンクション透過性を上昇させるが、遺伝的肥満は消化管透過性を上昇させない (2010)
  • Author(s): 鈴木卓弥、原博、高脂肪食は
  • Organizer: 2009年度日本栄養食糧学会
  • Place of Presentation: 徳島
  • Year and Date: 2010-05-23
• [Presentation] 高脂肪食は、小腸タイトジャンクション透過性を上昇させるが、遺伝的肥満は消化管透過性を上昇させない (2010)
  • Author(s): 鈴木卓弥、原博
  • Organizer: 日本栄養食糧学会
  • Place of Presentation: 徳島
  • Year and Date: 2010-05-23
• [Remarks] 研究室
  • URL: http://home.hiroshima-u.ac.jp/douri/Suzukigroup/Toppage.html