Role of CaSR as dietary peptide sensor and search for dietary protein receptor in the gut

• Project/Area Number: 21780118
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Food science
• Research Institution: Hokkaido University
• Principal Investigator: HIRA Tohru Hokkaido University, 大学院・農学研究院, 助教 (10396301)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: カルシウム感知受容体 / 消化管ホルモン / コレシストキニン / 食品ペプチド / 食品たんぱく質 / Calcium-sensing receptor / 受容体

Research Abstract

In this research project, we have investigated the function of calcium-sensing receptor (CaSR) as the receptor for luminal dietary peptides in gastrointestinal endocrine cells. Secretions of a gut hormone CCK induced by various dietary peptides were partially inhibited by the presence of CaSR antagonists. CaSR-expressing kidney cells also responded to various dietary peptides. These results suggest that CaSR is one of the receptor for dietary peptides in the gastrointestinal tract.

Research Products

• [Journal Article] Soybean <beta>51-63 peptide stimulates cholecystokinin secretion via a calcium-sensing receptor in enteroendocrine STC-1 cells (2010)
  • Author(s): Shingo Nakajima, Tohru Hira, Yuzuru Eto, Kozo Asano, Hiroshi Hara
  • Journal Title: Regulatory Peptides Vol.159(1-3) Pages: 148-155
  • Peer Reviewed
• [Journal Article] Soybean <beta> 51-63 peptide stimulates cholecystokinin secretion via a calcium-sensing receptor in enteroendocrine STC-1 cells (2010)
  • Author(s): Nakajima S, Hira T, Eto Y, Asano K.Hara H
  • Journal Title: Regulatory Peptides 159(1-3) Pages: 148-155
  • Peer Reviewed
• [Presentation] CCK産生細胞においてCalcium-sensing receptorはペプトン受容体として機能する (2010)
  • Author(s): 中島進吾、比良徹、Sufian Kaosar、江藤譲、原博
  • Organizer: 第64回日本栄養・食糧学会大会
  • Place of Presentation: アスティ徳島(徳島県)
  • Year and Date: 2010-05-23
• [Presentation] Calcium-sensing receptor is a sensor for dietary peptides to stimulate cholecystokinin secretion in the enteroendocrine cell line STC-1 (2010)
  • Author(s): Shingo Nakajima、Tohru Hira、Md Kaosar, Niaz Bin Sufian, Yuzuru Eto、Hiroshi Hara
  • Organizer: The 18th International Symposium on Regulatory Peptides
  • Place of Presentation: Europa Hotel Belfast (Belfast, UK)
• [Presentation] ラットにおいてProtamine経口投与は血糖上昇を抑制する (2009)
  • Author(s): 村松茉耶、比良徹、江藤譲、原博
  • Organizer: 平成21年度第二回合同学術講演会
  • Place of Presentation: 帯広市十勝プラザ(帯広市)
  • Year and Date: 2009-11-28
• [Presentation] ラットにおいて Protamine 経口投与は血糖上昇を抑制する (2009)
  • Author(s): 村松茉耶、比良徹、江藤譲、原博
  • Organizer: 平成21年度第二回合同学術講演会
  • Place of Presentation: 帯広市十勝プラザ
  • Year and Date: 2009-11-28