| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Research Abstract |
Non-obesity type 2 diabetic male GK rats were used to elucidate the effect of dietary zinc on insulin resistant diabetes and on insulin secretion. After 22 weeks of feeding of experimental diets starting at 10 weeks old, the fasting plasma glucose level of rats fed with diets containing the excess amount of zinc was found to be significantly lower than that of the pair-fed rats. Although statistical significant difference was not clear, it also had a tendency to be lower than the plasma glucose level of rats fed with zinc-deficient diets. The result suggests the positive effect of excess dietary zinc to suppress the fasting plasma glucose level. In addition, the effects of dietary zinc on SDT, SD and GK rats fed with the diet containing excess levels of dietary fat was also examined.
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