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An analysis of the effect of dietary zinc on age-related insulin resistant diabetes

Research Project

Project/Area Number 21780120
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Food science
Research InstitutionTohoku University

Principal Investigator

GOTO Tomoko  Tohoku University, 大学院・農学研究科, 助教 (00342783)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords亜鉛摂取 / 加齢 / インスリン抵抗性 / 糖尿病 / ラット
Research Abstract

Non-obesity type 2 diabetic male GK rats were used to elucidate the effect of dietary zinc on insulin resistant diabetes and on insulin secretion. After 22 weeks of feeding of experimental diets starting at 10 weeks old, the fasting plasma glucose level of rats fed with diets containing the excess amount of zinc was found to be significantly lower than that of the pair-fed rats. Although statistical significant difference was not clear, it also had a tendency to be lower than the plasma glucose level of rats fed with zinc-deficient diets. The result suggests the positive effect of excess dietary zinc to suppress the fasting plasma glucose level. In addition, the effects of dietary zinc on SDT, SD and GK rats fed with the diet containing excess levels of dietary fat was also examined.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (31 results)

All 2011 2010 2009 Other

All Journal Article (12 results) (of which Peer Reviewed: 8 results) Presentation (16 results) Book (2 results) Remarks (1 results)

  • [Journal Article] ラットの授乳期の低亜鉛栄養状態が成熟後の味嗜好調節系に及ぼす影響2010

    • Author(s)
      辻村夏來、後藤知子、白川仁、駒井三千夫
    • Journal Title

      日本味と匂学会誌 17巻

      Pages: 333-334

    • NAID

      110008451351

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 食品I2010

    • Author(s)
      後藤知子、白川仁
    • Journal Title

      バイオサイエンスとインダストリー 68巻

      Pages: 260-261

    • Related Report
      2010 Final Research Report
  • [Journal Article] 味覚機能への亜鉛酵素「炭酸脱水酵素」の寄与2010

    • Author(s)
      駒井三千夫、後藤知子、大日向耕作、白川仁
    • Journal Title

      Biomedical Research on Trace elements Vol.21

      Pages: 38-42

    • NAID

      10027734242

    • Related Report
      2010 Final Research Report
  • [Journal Article] 味覚機能への亜鉛酵素「炭酸脱水酵素」の寄与2010

    • Author(s)
      駒井三千夫、後藤知子、大日向耕作、白川仁
    • Journal Title

      Biomedical Research on Trace elements

      Volume: 21 Pages: 38-42

    • NAID

      10027734242

    • Related Report
      2010 Annual Research Report
  • [Journal Article] ラットの授乳期の低亜鉛栄養状態が成熟後の味嗜好調節系に及ぼす影響2010

    • Author(s)
      辻村夏來、後藤知子、白川仁、駒井三千夫
    • Journal Title

      日本味と匂学会誌

      Volume: 17 Pages: 333-334

    • NAID

      110008451351

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 学会見聞録 農芸化学会大会 食品I2010

    • Author(s)
      後藤知子、白川仁
    • Journal Title

      バイオサイエンスとインダストリー

      Volume: 68 Pages: 260-261

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Vitamin K suppresses the lipopolysaccharide-induced expression of inflammatory cytokines in cultured macrophage-like cells via the inhibition of the activiation of nuclear factor kappaB through the repression of IKKalpha/beta phosphorylation2010

    • Author(s)
      Ohsaki Y, Shirakawa H, Miura A, Giriwono PE, Sato S, Ohashi A, Iribe M, Goto T, Komai M
    • Journal Title

      The Journal of Nutritional Biochemistry

      Volume: 21 Pages: 1120-1126

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vitamin K suppresses the lipopolysaccharide-induced expression of inflammatory cytokines in cultured macrophage-like cells via the inhibition of the activiation of nuclear factor kappaB through the repression of IKKalpha/beta phosphorylation.2009

    • Author(s)
      Ohsaki Y, Shirakawa H, Miura A, Giriwono PE, Sato S, Ohashi A, Iribe M, Goto T, Komai M.
    • Journal Title

      The Journal of Nutritional Biochemistry Vol.21

      Pages: 1120-1126

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 食餌中亜鉛がラットの味覚感受性と食塩嗜好に及ぼす影響2009

    • Author(s)
      後藤知子、白川仁、駒井三千夫
    • Journal Title

      日本味と匂学会誌 16巻

      Pages: 267-268

    • NAID

      110007568686

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      Ohinata K, Takemoto M, Kawanago M, Fushimi S, Shirakawa H, Goto T, Asakawa A, Komai M.
    • Journal Title

      Journal of Nutrition Vol.16

      Pages: 611-616

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 食餌中亜鉛がラットの味覚感受性と食塩嗜好に及ぼす影響2009

    • Author(s)
      後藤知子、白川仁、駒井三千夫
    • Journal Title

      日本味と匂学会誌 16

      Pages: 267-268

    • NAID

      110007568686

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Orally administered zinc increases food intake via vagal stimulation in rats2009

    • Author(s)
      Ohinata K, Takemoto M, Kawanago M, Fushimi S, Shirakawa H, Goto T, Asakawa A, Komai M
    • Journal Title

      Journal of Nutrition 139

      Pages: 611-616

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 妊娠期の極端な食餌制限が生後仔ラットの食塩嗜好および血中亜鉛濃度に及ぼす影響2011

    • Author(s)
      森恵見、鈴木美季子、後藤知子、駒井三千夫、木村修一
    • Organizer
      第65回日本栄養・食糧学会大会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-15
    • Related Report
      2010 Final Research Report
  • [Presentation] 長期間の亜鉛摂取が2型糖尿病モデルGKラットの糖代謝に及ぼす影響2011

    • Author(s)
      後藤知子、白川仁、駒井三千夫
    • Organizer
      第65回日本栄養・食糧学会大会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Effects of short-term zinc deficiency on salt preference in rats.2010

    • Author(s)
      Goto T, Shirakawa H, Komai M.
    • Organizer
      The 60^<th> Fujihara Seminar
    • Place of Presentation
      大阪
    • Year and Date
      2010-10-30
    • Related Report
      2010 Final Research Report
  • [Presentation] Effects of short-term zinc deficiency on salt preference in rats.2010

    • Author(s)
      Goto T, Shirakawa H, Komai M
    • Organizer
      The 60^<th> Fujihara Seminar Zinc Signaling and Cellular Functions
    • Place of Presentation
      大阪
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Orally administered zinc increases food intake via vagus nerve signal transduction in SD rats.2010

    • Author(s)
      Komai M, Ohinata K, Takemoto M, Kawanago M, Fushimi S, Shirakawa H, Goto T, Asakawa A
    • Organizer
      The 60^<th> Fujihara Seminar Zinc Signaling and Cellular Functions
    • Place of Presentation
      大阪
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 授乳期における低亜鉛栄養状態が仔ラットの成熟後の塩味嗜好調節系に及ぼす影響2010

    • Author(s)
      辻村夏來、後藤知子、白川仁、駒井三千夫
    • Organizer
      第21回日本微量元素学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-07-04
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] ルペオールの経口投与による高血圧症改善2010

    • Author(s)
      山口恵理、Ardiansyah A、樋渡一之、畠恵司、後藤知子、白川仁、駒井三千夫
    • Organizer
      第64回日本栄養・食料学会大会
    • Place of Presentation
      徳島
    • Year and Date
      2010-05-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 妊娠期における極端な食事制限が生後仔ラットの食塩嗜好に及ぼす影響2010

    • Author(s)
      森恵見、鈴木美季子、後藤知子、駒井三千夫、木村修一
    • Organizer
      第64回日本栄養・食料学会大会
    • Place of Presentation
      徳島
    • Year and Date
      2010-05-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 授乳期における低亜鉛栄養状態が仔ラットの成熟期の塩味感覚受容調節系に及ぼす影響2010

    • Author(s)
      駒井三千夫、辻村夏來、後藤知子、白川仁
    • Organizer
      第64回日本栄養・食料学会大会
    • Place of Presentation
      徳島
    • Year and Date
      2010-05-22
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Anti-oxidative activity of fermented barley extract protects live from LPS induced inflammation.2010

    • Author(s)
      Giriwono PE, 白川仁、外園英樹、大崎雄介、後藤知子、Komai M
    • Organizer
      第64回日本栄養・食料学会大会
    • Place of Presentation
      徳島
    • Year and Date
      2010-05-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 食餌中亜鉛がラットの食塩嗜好調節系に及ぼす影響2010

    • Author(s)
      後藤知子、白川仁、駒井三千夫
    • Organizer
      日本農芸化学会2010年度大会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-30
    • Related Report
      2010 Final Research Report
  • [Presentation] Effects of dietary zinc on taste sensitivity and salt preference in rats.2009

    • Author(s)
      Goto T,Shirakawa H, Komai M.
    • Organizer
      日本味と匂学会第43回大会
    • Place of Presentation
      北海道
    • Year and Date
      2009-09-02
    • Related Report
      2010 Final Research Report
  • [Presentation] Effects of dietary zinc on taste sensitivity and salt preference in rats2009

    • Author(s)
      Tomoko Goto, Hitoshi Shirakawa, Michio Komai
    • Organizer
      日本味と匂学会第43回大会
    • Place of Presentation
      旭川市
    • Year and Date
      2009-09-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 味覚機能への亜鉛酵素「炭酸脱水酵素」の寄与2009

    • Author(s)
      駒井三千夫、後藤知子、大日向耕作、白川仁
    • Organizer
      第20回日本微量元素学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-05
    • Related Report
      2010 Final Research Report
  • [Presentation] 亜鉛欠乏ラットにおける血漿イオン化カルシウム濃度の変化2009

    • Author(s)
      後藤知子、白川仁、古川勇次、駒井三千夫
    • Organizer
      第63回日本栄養・食糧学会大会
    • Place of Presentation
      長崎
    • Year and Date
      2009-05-22
    • Related Report
      2010 Final Research Report
  • [Presentation] 母ラットの授乳期における亜鉛栄養状態と次代ラットの成熟後の食塩嗜好調節系2009

    • Author(s)
      辻村夏來、後藤知子、白川仁、駒井三千夫
    • Organizer
      第63回日本栄養・食糧学会大会
    • Place of Presentation
      長崎
    • Year and Date
      2009-05-22
    • Related Report
      2010 Final Research Report
  • [Book] 子どもの食と栄養-理論と演習・実習-第2版第6章幼児期の栄養と食生活(呉繁夫、廣野治子編)2010

    • Author(s)
      後藤知子
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2010 Final Research Report
  • [Book] 子どもの食と栄養-理論と演習・実習-第2版 第6章 幼児期の栄養と食生活2010

    • Author(s)
      後藤知子(呉繁夫、廣野治子編)
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2010 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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