Function of taste bud cells other than sweet, umami, bitter, and sour taste receptor cells

• Project/Area Number: 21780121
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Food science
• Research Institution: The University of Tokyo
• Principal Investigator: OHMOTO Makoto The University of Tokyo, 大学院・農学生命科学研究科, 特任助教 (30447362)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 味覚 / 味蕾

Research Abstract

In order to analyze the physiological functions of the taste bud cells other than sweet, umami, bitter, and sour taste receptor cells (TRCs), we obtained the molecular characteristics of taste bud cells. Three genes were specifically expressed in the taste bud cells other than sweet, umami, bitter, and sour TRCs.

Research Products

• [Journal Article] Skn-1a (Pou2f3) specifies taste receptor cell lineage. (2011)
  • Author(s): Matsumoto I, Ohmoto M, Narukawa M, Yoshihara Y, Abe K.
  • Journal Title: Nature Neuroscience vol.14 Pages: 685-687
  • Peer Reviewed
• [Journal Article] Mutually exclusive expression of Gαia and G α 14 reveals diversification of taste receptor cells in zebrafish. (2011)
  • Author(s): Ohmoto M, Okada S, Nakamura S, Abe K, Matsumoto I.
  • Journal Title: Journal of Comparative Neurology vol.519 Pages: 1616-1629
  • Peer Reviewed
• [Journal Article] Mutually exclusive expression of Gαia and Gα14 reveals diversification of taste receptor cells in zebrafish. (2011)
  • Author(s): Ohmoto M
  • Journal Title: Journal of Comparative Neurology Volume: (in press)(掲載確定)
  • Peer Reviewed
• [Journal Article] Genetic tracing of the neural pathway for bitter taste in t2r5-WGA transgenic mice. (2010)
  • Author(s): Ohmoto M, Maeda N, Abe K, Yoshihara Y, Matsumoto I.
  • Journal Title: Biochemical and Biophysical Research Communications vol.400 Pages: 734-738
  • Peer Reviewed
• [Journal Article] Genetic tracing of the neural pathway for bitter taste in t2r5 -WGA transgenic mice. (2010)
  • Author(s): Ohmoto M
  • Journal Title: Biochemical and Biophysical Research Communication Volume: 400 Pages: 234-238
  • Peer Reviewed
• [Journal Article] Spatial differences in molecular characteristics of the pontine parabrachial nucleus. (2009)
  • Author(s): Maeda N, Onimura M, Ohmoto M, Inui T, Yamamoto T, Matsumoto I, Abe K.
  • Journal Title: Brain Research vol.1296 Pages: 24-34
  • Peer Reviewed
• [Journal Article] Spatial differences in molecular characteristics of the pontine parabrachial nucleus (2009)
  • Author(s): Maeda N.
  • Journal Title: Brain Research 1296 Pages: 24-34
  • Peer Reviewed
• [Presentation] 味蕾に発現する塩化物イオンチャネルの同定 (2011)
  • Author(s): 黒川あずさ、應本真、阿部啓子、三坂巧
  • Organizer: 日本農芸化学会2011年度大会
  • Place of Presentation: 京都
• [Presentation] Gα genes expressed in fish taste receptor cells. (2011)
  • Author(s): Ohmoto M, Okada S, Nakamura S, Abe K, Matsumoto I.
  • Organizer: 33rd Annual Meeting of Association for Chemoreception Sciences
  • Place of Presentation: St.Pete Beach, Florida
• [Presentation] Expression of G protein in fish gustatory system reveals the diversification of fish taste receptor cells. (2010)
  • Author(s): Ohmoto M, Okada S, Nakamura S, Abe K, Matsumoto I.
  • Organizer: The 8th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception (YR mami Forum 2010)
  • Place of Presentation: Fukuoka
• [Presentation] Spatial differences in molecular characteristics of the pontine parabrachial nucleus. (2010)
  • Author(s): Maeda N, Onimura M, Ohmoto M, Inui T,Yamamoto T, Matsumoto I, Abe K.
  • Organizer: 32nd Annual Meeting of Association for Chemoreception Sciences
  • Place of Presentation: St.Pete Beach, Florida