| Project/Area Number |
21780125
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | Kobe University |
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Principal Investigator |
NISHIUMI Shin Kobe University, 医学研究科, 特命助教 (20514706)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | アリール炭化水素受容体 / メタボローム解析 / 代謝物 / メタボロミクス / ガスクロマトグラフ質量分析計 / 代謝産物 / 質量分析計 |
|---|
| Research Abstract |
The aryl hydrocarbon receptor (AhR) is known to be activated by its ligands, resulting in regulation of various genes. However, the biological functions of AhR have been not elucidated yet. Therefore, the influence of AhR on the biological functions was investigated by the metabolome analysis, which is the comprehensive analysis of metabolites. As a result, it was demonstrated that the activation of AhR leads to alteration of various metabolites. In addition, it was found that the metabolite profile is different between the presence and absence of AhR expression.
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