Control of expression of genes related to metabolic syndrome by food components

• Project/Area Number: 21780130
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Food science
• Research Institution: Saga University
• Principal Investigator: NAGAO Koji Saga University, 農学部, 准教授 (10336109)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: メタボリックシンドローム / 脂肪組織 / 疾患遺伝子 / 食環境

Research Abstract

Nonalcoholic fatty liver disease (NAFLD) is emerging as the most common liver disease in metabolic syndrome. We found that the dietary intake of powdered whole Panellus serotinus (Mukitake) and its extracts alleviate NAFLD in obese, diabetic db/db mice. Our study demonstrated that Mukitake displays at least two different physiological actions that alleviate NAFLD : one through the reduction of inflammatory damage by its suppression in MCP-1 production and the other through an increase of the serum adiponectin level and the prevention of visceral fat accumulation.

Research Products

• [Journal Article] Mukitake mushroom (Panellus serotinus) alleviates nonalcoholic fatty liver disease through the suppression of monocyte chemoattractant protein-1 production in db/db mice. (2010)
  • Author(s): K.Nagao, N.Inoue, M.Inafuku, B.Shirouchi, T.Morooka, S.Nomura, N.Nagamori, T.Yanagita
  • Journal Title: J.Nutr.Biochem 21巻 Pages: 418-423
  • Peer Reviewed
• [Journal Article] Effects of citrus auraptene (7-geranyloxycoumarin) on hepatic lipid metabolism in vitro and in vivo (2010)
  • Author(s): K.Nagao, N.Yamano, B.Shirouchi, N.Inoue, S.Murakami, T.Sasaki, T.Yanagita
  • Journal Title: J.Agric.Food Chem. 51巻 Pages: 9028-9032
  • Peer Reviewed
• [Journal Article] Medium-chain fatty acids : Functional lipids for the prevention and treatment of the metabolic syndrome. (2010)
  • Author(s): K.Nagao, T.Yanagita
  • Journal Title: Pharm.Res. 61巻 Pages: 208-12
  • Peer Reviewed
• [Journal Article] Dietary saponins of sea cucumber alleviate orotic acid-induced fatty liver in rats via PPAR alpha and SREBP-1c signaling. (2010)
  • Author(s): XQ.Hu, YM.Wang, JF.Wang, Y.Xue, ZJ.Li, K.Nagao, T.Yanagita, CH.Xue
  • Journal Title: Lipids Health Dis. 9巻 Pages: 1-9
  • Peer Reviewed
• [Journal Article] Mukitake mushroom (Panellus serotinus) alleviates nonalcoholic fatty liver disease through the suppression of monocyte chemoattractant protein-1 production in db/db mice. (2010)
  • Author(s): Nagao K., N.Inoue, M.Inafuku, B.Shirouchi, T.Morooka, S.Nomura, N.Nagamori, T.Yanagita
  • Journal Title: J.Nutr.Biochem. Volume: 21 Pages: 418-423
  • Peer Reviewed
• [Journal Article] Effects of citrus auraptene (7-geranyloxycoumarin) on hepatic lipid metabolism in vitro and in vivo. (2010)
  • Author(s): Nagao K., N.Yamano, B.Shirouchi, N.Inoue, S.Murakami, T.Sasaki, T.Yanagita
  • Journal Title: J.Agric.Food Chem. Volume: 58 Pages: 9028-9032
  • Peer Reviewed
• [Journal Article] Medium-chain fatty acids : Functional lipids for the prevention and treatment of the metabolic syndrome. (2010)
  • Author(s): K.Nagao, T.Yanagita
  • Journal Title: Pharm. Res. 61 Pages: 208-212
  • Peer Reviewed
• [Journal Article] Dietary soy protein isolate, and its undigested high molecular fraction upregulate hepatic ATP-binding cassette transporter G5 and ATP-binding cassette transporter G8 mRNA and increase biliary secretion of cholesterol in rats. (2009)
  • Author(s): I.Ikeda, M.Kudo, T.Hamada, K.Nagao, Y.Oshiro, M.Kato, T.Sugawara, T.Yamahira, H.Ito, S.Tamaru, M.Sato, K.Imaizumi, S.Nagaoka, T.Yanagita
  • Journal Title: J.Nutr.Sci.Vitaminol 55巻 Pages: 252-256
  • NAID: 10025971374
  • Peer Reviewed
• [Journal Article] Dietary soy protein isolate and its undigested high molecular fraction upregulate hepatic ATP-binding cassette transporter G5 and ATP-binding cassette transporter G8 Mrna and increase biliary secretion of cholesterol in rats. (2009)
  • Author(s): I.Ikeda, M.Kudo, T.hamada, K.Nagao, Y.Oshiro, M.Kato, T.Sugawara, T.Yamahira, H.Ito, S.Tamaru, M.Sato, K,Imaizumi, S.Nagaoka, T.Yanagita
  • Journal Title: J.Nutr. Sci. Vitaminol. 55 Pages: 252-256
  • NAID: 10025971374
  • Peer Reviewed
• [Journal Article] Dietary saponins of sea cucumber alleviate orotic acid-induced fatty liver in rats via PPAR alpha and SREBP-lc signaling. (2009)
  • Author(s): XQ.Hu. YM. Wang, JF.Wang, Y.Xue, ZJ.Li, K.Ngao, T.Yagita, CH.Xue
  • Journal Title: Lipids Healt Dis 9 Pages: 1-9
  • Peer Reviewed
• [Presentation] 機能性脂質の働きとメタボリックシンドロームの予防・改善 (2010)
  • Author(s): 永尾晃治
  • Organizer: 平成22 年度日本ビタミン学会市民公開講演会
  • Place of Presentation: 佐賀市
  • Year and Date: 2010-11-06
• [Presentation] 機能性脂質の働きとメタボリックシンドロームの予防・改善 (2010)
  • Author(s): 永尾晃治
  • Organizer: 平成22年度日本ビタミン学会市民公開講演会
  • Place of Presentation: 佐賀市
  • Year and Date: 2010-11-06
• [Presentation] 機能性脂質によるメタボリックシンドロームの予防・改善 (2010)
  • Author(s): 永尾晃治
  • Organizer: 平成22 年度日本油化学会関西支部講演会
  • Place of Presentation: 佐賀市
  • Year and Date: 2010-08-07
• [Presentation] 機能性脂質によるメタボリックシンドロームの予防・改善 (2010)
  • Author(s): 永尾晃治
  • Organizer: 平成22年度日本油化学会関西支部講演会
  • Place of Presentation: 佐賀市
  • Year and Date: 2010-08-07
• [Presentation] 食品成分を用いたメタボリックシンドローム予防・改善への試み (2010)
  • Author(s): 永尾晃治
  • Organizer: 平成22年度日本栄養・食糧学会九州・沖縄支部後悔市民講演会
  • Place of Presentation: 長崎市
  • Year and Date: 2010-04-24
• [Presentation] 機能性脂質の働きとメタボリックシンドロームの予防・改善に関する研究 (2009)
  • Author(s): 永尾晃治
  • Organizer: 第63回日本栄養・食糧学会大会
  • Place of Presentation: 長崎市
  • Year and Date: 2009-05-20
• [Presentation] 機能性脂質によるメタボリックシンドロームの予防・改善に関する研究 (2009)
  • Author(s): 永尾晃治
  • Organizer: 第63回日本栄養・食糧学会大会
  • Year and Date: 2009-05-20
• [Presentation] Effect of dietary DHA-PC on lipid metabolism in obese rats. (2009)
  • Author(s): Koji Nagao
  • Organizer: 100th American oil chemist' society annual meeting & expo
  • Place of Presentation: Orlando(USA)
  • Year and Date: 2009-05-04
• [Presentation] Effect of dietary DHA-PC on lipid metabolism in obese rats. (2009)
  • Author(s): K.Nagao
  • Organizer: 100th American oil chemist society annual meeting, expo
  • Place of Presentation: Orlando (USA)
  • Year and Date: 2009-05-04