Mechanism of the enhancement of hepatic insulin action induced by protein malnutrition
| Project/Area Number |
21780134
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | Nippon Medical School |
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Principal Investigator |
SUZUKI Yuka (SUZUKI TOYOSHIMA Yuka) 日本医科大学, 老人病研究所, 助教 (70516070)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | インスリン / 肝臓 / タンパク質栄養 / インスリン受容体基質 |
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| Research Abstract |
Protein malnutrition induces lipid accumulation in the liver, which was liked with the enhancement of insulin signaling in the liver. Furthermore, in contrast to the liver, in white adipose tissue(WAT), protein malnutrition suppresses insulin action. Taken together with our results, when energy utilization is reduced under protein malnutrition, energy that is not utilized is preferentially incorporated into the liver and synthesized to lipids. The enhancement of insulin signaling in the liver and the suppression of insulin signaling in WAT may play important roles in the preferential distribution of lipids in the liver during protein malnutrition.
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Report
(4 results)
Research Products
(10 results)
