Studies on the protective effects of polyunsaturated fatty acids in Alzheimer's disease.

• Project/Area Number: 21780139
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Food science
• Research Institution: Nihon University (2010); National Institute for Longevity Sciences,NCGG (2009)
• Principal Investigator: HOSONO Takashi Nihon University, 生物資源科学部, 助手 (80445741)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 食品機能 / アルツハイマー病 / 多価不飽和脂肪酸 / アラキドン酸 / ドコサヘキサエン酸 / アミロイドβ前駆タンパク質 / アミロイドβ

Research Abstract

In this study, we examined the effects of dietary supplementation with polyunsaturated fatty acid (arachidonic acid or docosahexaenoic acid) on Alzheimer's disease pathology. Polyunsaturated fatty acid diet prevents memory impairment in Alzheimer model Tg2576 mice. APP processing to generate soluble APP and Aβ synthesis were enhanced, but the Aβ1-42/Aβ1-40 ratio was decreased in Tg2576 mice fed with the arachidonic acid or docosahexaenoic acid diet. These findings suggest that polyunsaturated fatty acid diet could prevent cognitive dysfunction, and alter APP processing and Aβ1-42/Aβ1-40 ratio in Tg2576 mice.

Research Products

• [Journal Article] Lipoprotein lipase is a novel amyloid β (Aβ)-binding protein that promotes glycosaminoglycan-dependent cellular uptake of Aβ in astrocytes. (2011)
  • Author(s): Nishitsuji K, Hosono T, Uchimura K, Michikawa M.
  • Journal Title: Journal of biological chemistry 286(8) Pages: 6393-6401
  • Peer Reviewed
• [Journal Article] Lipoprotein lipase is a novel amyloid beta (Aβ)-binding protein that promotes glycosaminoglycan-dependent cellular uptake of Aβ in astrocytes. (2011)
  • Author(s): Nishitsuji K
  • Journal Title: Journal of biological chemistry Volume: 286(8) Pages: 6393-6401
  • Peer Reviewed
• [Journal Article] Verification of the antidiabetic effects of cinnamon (Cinnamomum zeylanicum) using insulin-uncontrolled type 1 diabetic rats and cultured adipocytes. (2010)
  • Author(s): Shen Y, Fukushima M, Ito Y, Muraki E, Hosono T, Seki T, Ariga T.
  • Journal Title: Bioscience, biotechnology, and biochemistry 74(12) Pages: 2418-2425
  • NAID: 10027727963
  • Peer Reviewed
• [Journal Article] Replacing white rice with pre-germinated brown rice mildly ameliorates hyperglycemia and imbalance of adipocytokine levels in type 2 diabetes model rats. (2010)
  • Author(s): Torimitsu M, Nagase R, Yanagi M, Homma M, Sasai Y, Ito Y, Hayamizu K, Nonaka S, Hosono T, Kise M, Seki T, Ariga T.
  • Journal Title: Journal of nutritional science and vitaminology 56 Pages: 287-292
  • NAID: 10026966020
  • Peer Reviewed
• [Journal Article] Homocysteine, another risk factor for Alzheimer disease, impairs apolipoprotein E3 function. (2010)
  • Author(s): Minagawa H, Watanabe A, Akatsu H, Adachi K, Ohtsuka C, Terayama Y, Hosono T, Takahashi S, Wakita H, Jung CG, Komano H, Michikawa M.
  • Journal Title: Journal of biological chemistry 285(49) Pages: 38382-38388
  • Peer Reviewed
• [Journal Article] Relationship between lipophilicity and inhibitory activity against cancer cell growth of nine kinds of alk(en)yl trisulfides with different side chains. (2010)
  • Author(s): Iitsuka Y, Tanaka Y, Hosono-Fukao T, Hosono T, Seki T, Ariga T.
  • Journal Title: Oncology research 18 Pages: 575-582
  • Peer Reviewed
• [Journal Article] Honokiol increases ABCA1 expression level by activating retinoid X receptor β. (2010)
  • Author(s): Jung CG, Horike H, Cha BY, Uhm KO, Yamauchi R, Yamaguchi T, Hosono T, Iida K, Woo JT, Michikawa M.
  • Journal Title: Biological & pharmaceutical bulletin 33 Pages: 1105-1111
  • Peer Reviewed
• [Journal Article] Verification of the Antidiabetic Effects of Cinnamon (Cinnamomum zeylanicum) Using Insulin-Uncontrolled Type 1 Diabetic Rats and Cultured Adipocytes. (2010)
  • Author(s): Shen Y
  • Journal Title: Bioscience, biotechnology, and biochemistry Volume: 74(12) Pages: 2418-25
  • Peer Reviewed
• [Journal Article] Replacing white rice with pre-germinated brown rice mildly ameliorates hyperglycemia and imbalance of adipocytokine levels in type 2 diabetesmodel rats. (2010)
  • Author(s): Torimitsu M
  • Journal Title: Journal of nutritional science and vitaminology Volume: 56 Pages: 287-292
  • Peer Reviewed
• [Journal Article] Homocysteine, another risk factor for Alzheimer's disease, impairs apolipoprotein E3 function. (2010)
  • Author(s): Minagawa H
  • Journal Title: Journal of biological chemistry Volume: 285(49) Pages: 38382-38388
  • Peer Reviewed
• [Journal Article] Relationship between lipophilicity and inhibitory activity against cancer cell growth of nine kinds of alk(en)yl trisulfides with different side chains. (2010)
  • Author(s): Iitsuka Y
  • Journal Title: Oncology research Volume: 18 Pages: 575-582
  • Peer Reviewed
• [Journal Article] Honokiol increases ABCA1 expression level by activating retinoid X receptor β. (2010)
  • Author(s): Jung CG
  • Journal Title: Biological & pharmaceutical bulletin Volume: 33 Pages: 1105-1111
  • Peer Reviewed
• [Journal Article] Apolipoprotein E4 (1-272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells. (2009)
  • Author(s): Nakamura T
  • Journal Title: Molecular Neurodegeneration 4 Pages: 1-11
  • Peer Reviewed
• [Journal Article] Diallyl trisulfide protects rats from carbon tetrachioride-induced liver in jury. (2009)
  • Author(s): Hosono-Fukao T
  • Journal Title: Journal of Nutrition 139 Pages: 2252-2256
  • Peer Reviewed
• [Presentation] 多価不飽和脂肪酸餌はLPSで誘導される脳内炎症を抑制する (2010)
  • Author(s): 細野崇
  • Organizer: 第29回日本認知症学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-11-05
• [Presentation] ガーリック香気成分diallyl trisulfideの強いがん細胞増殖抑制活性は、システインとの反応性に起因する (2010)
  • Author(s): 細野崇
  • Organizer: 第15回日本フードファクター学会
  • Place of Presentation: 仙台
  • Year and Date: 2010-10-04
• [Presentation] 必須脂肪酸経口摂取による脳内アミロイドβ蛋白沈着抑制 (2009)
  • Author(s): 細野崇
  • Organizer: 第28回日本認知症学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2009-11-20