Analysis of the target protein which interacts with an anti-fouling isocyanide and proteomic analyses when anti-fouling substances acted against to the barnacle cyprid

• Project/Area Number: 21780175
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General fisheries
• Research Institution: Tokyo University of Agriculture and Technology
• Principal Investigator: KITANO Yoshikazu Tokyo University of Agriculture and Technology, 大学院・農学研究院, 准教授 (10302910)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: フジツボ / キプリス幼生 / 付着阻害活性 / イソシアノ基 / イソニトリル / 付着阻害 / 蛍光プローブ

Research Abstract

Bio-organic studies were carried out to elucidate the mechanism for the expression of anti-fouling activity against the cyprid larva of the barnacle. Analysis of the target protein which interacts with anti-fouling active isocyanides and proteomic analyses when anti-fouling substances acted to the barnacle cyprids were examined. As a result, it was suggested that there was a 53 KDa protein which interacts with an isocyano compounds.

Research Products

• [Journal Article] Anti-barnacle activity of novel simple alkyl isocyanides derived from citronellol (2011)
  • Author(s): 北野克和、秋間千佳、吉村えり奈、野方靖行
  • Journal Title: Biofouling 27(2) Pages: 201-205
  • Peer Reviewed
• [Journal Article] Anti-barnacle activity of novel simple alkyl isocyanides derived from citronellol (2011)
  • Author(s): 北野克和(北野克和)
  • Journal Title: Biofouling Volume: 27 Pages: 201-205
  • Peer Reviewed
• [Presentation] 金属試薬を用いないアルコールからのワンポットイソニトリル合成法 (2011)
  • Author(s): 岡田郁(北野克和)
  • Organizer: 日本農芸化学会2011 年度大会
  • Place of Presentation: 京都女子大学(京都)
  • Year and Date: 2011-03-26
• [Presentation] Bio-organic studies on the cypris larva of the barnacle with fluorescence-labeled probes (2010)
  • Author(s): 秋間千佳(北野克和)
  • Organizer: 9th International Marine Biotechnology Conference
  • Place of Presentation: チンタオ(中国)
  • Year and Date: 2010-10-10
• [Presentation] クロロリン酸化合物を用いたホルムアミドからのイソニトリル合成法 (2010)
  • Author(s): 小林弦貴(北野克和)
  • Organizer: 日本化学会第90春季年会
  • Place of Presentation: 近畿大学(大阪)
  • Year and Date: 2010-03-28