| Project/Area Number |
21780180
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General fisheries
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| Research Institution | University of Miyazaki |
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Principal Investigator |
KONO Tomoya University of Miyazaki, IR推進機構, 助教 (60527547)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 魚病 / 免疫 / サイトカイン / バイオマーカー / フグ / 発現解析 / IL-2 / TGF-β1 / インターロイキン17(IL-17) / 炎症反応 / リポポリサッカライド(LPS) |
|---|
| Research Abstract |
It was found that teleost fish possesses interleukin-17 family genes including IL-17A/F, IL-17C and IL-17D. Recently, I found a novel type of IL-17 gene named IL-17N unknown in other vertebrates. Moreover, it was found that IL-17N gene does not exist on the genome of insect and amphibians by synteny analysis. Therefore, it was suggested that IL-17N molecule is characteristic for teleost fish. The expression analysis of cytokine genes in fish infected with pathogen suggested that cytokines to control cell proliferation such as IL-2 and TGF-・1 play important role at early stage of immune response. Consequently, these cytokines will be important for analyzing the health condition of fish.
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