Molecular mechanism of feeding regulation in larval fish

• Project/Area Number: 21780181
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General fisheries
• Research Institution: Kitasato University
• Principal Investigator: MIZUSAWA Kanta 北里大学, 海洋生命科学部, 講師 (70458743)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 遺伝子 / ゼブラフィッシュ / 仔魚 / 摂食 / 成長 / 発光ダイオード / マイクロアレイ / メラニン凝集ホルモン / 孵化仔魚 / LED / MCH / 食欲 / 摂餌 / 受容体 / 光 / 背地応答 / 転写調節

Research Abstract

This study shows that the feeding and growth of larval zebrafish are modified by certain wavelengths and some hormone-relating genes, which include melanin-concentrating hormone, exhibit changes in expression levels in response to certain wavelengths. Molecular cloning has identified a mammalian-type melanin-concentrating hormone receptor, which is expressed in the brain but not in the skin.

Research Products

• [Journal Article] Food deprivation increases the expression of the prepro-orexin gene in the hypothalamus of the barfin flounder (2012)
  • Author(s): Amiya N, Mizusawa K, Kobayashi Y, Yamanome T, Amano M, Takahashi A
  • Journal Title: Verasper moseri. Zool. Sci. Volume: 29 Issue: 1 Pages: 42-48
  • DOI: 10.2108/zsj.29.43
  • Peer Reviewed
• [Journal Article] 魚類・光・内分泌～体色と食欲の深い仲 (2011)
  • Author(s): 高橋明義, 小林勇喜, 山野目健, 水澤寛太
  • Journal Title: ビオフィリア Volume: 7 Pages: 31-36
  • URL: http://annex.biophilia.jp/index.php/biophilia/article/view/397
• [Journal Article] Signalling pathway of goldfish melanin-concentrating hormone receptors 1 and 2 (2011)
  • Author(s): Hamamoto A, Mizusawa K, Takahashi A, Saito Y
  • Journal Title: Regul. Pept. Volume: 169 Issue: 1-3 Pages: 6-12
  • DOI: 10.1016/j.regpep.2011.04.001
  • Peer Reviewed
• [Journal Article] Inhibiting roles of melanin-concentrating hormone for skin pigment dispersion in barfin flounder, Verasper moseri (2011)
  • Author(s): Mizusawa, K., Kobayashi, Y., Sunuma, T., Asahida, T., Saito, Y., Takahashi, A.
  • Journal Title: General and Comparative Endocrinology Volume: 171 Pages: 75-81
  • Peer Reviewed
• [Journal Article] Molecular cloning and expression of two melanin-concentrating hormone receptors mgoldfish (2009)
  • Author(s): Mizusawa K
  • Journal Title: Peptides 30 Pages: 1990-1996
  • Peer Reviewed
• [Journal Article] キンギョ・メラニン凝集ホルモン受容体の同定と発現解析 (2009)
  • Author(s): 水澤寛太
  • Journal Title: 比較内分泌学 35 Pages: 308-311
  • NAID: 10025870764
• [Presentation] The MCH System of Shark is More Closely Related to the MCH System of Mammals than That of Teleosts (2012)
  • Author(s): Mizusawa K
  • Organizer: The 7th Congress of the Asia and Oceania Society for Comparative Endocrinology
  • Place of Presentation: Kuala Lumpur, Malaysia
  • Year and Date: 2012-03-05
• [Presentation] マツカワ体色調節における2型メラニン凝集ホルモンの役割 (2010)
  • Author(s): 水澤寛太、小林勇喜、須沼俊和、齋藤大輔、高橋明義
  • Organizer: 第35回日本比較内分泌学会
  • Place of Presentation: グランシップ 静岡県コンベンションアーツセンター(静岡市)
  • Year and Date: 2010-11-19
• [Presentation] シュモクザメのメラニン凝集ホルモン受容体のcDNAクローニング (2010)
  • Author(s): 水澤寛太
  • Organizer: 日本水産学会春季大会
  • Place of Presentation: 日本大学藤沢キャンパス(神奈川県)
  • Year and Date: 2010-03-29
• [Presentation] Characterization of two melanin-concentrating hormone receptor subtypes in gold fish (2009)
  • Author(s): Mizusawa K
  • Organizer: 16th International Congress of Comparative Endocrinology
  • Place of Presentation: The University of Hong Kong(Hong Kong)
  • Year and Date: 2009-06-23
• [Remarks] ホームページ等研究代表者の所属する研究室のホームページ
  • URL: http://www.kitasato-u.ac.jp/fish/contents/lab/l12/index.htm